Table 3.
Unadjusted and Covariate Adjusted Relative Risk for Blood Product Utilization and Post-operative Events in Patients Receiving Aprotinin when Compared to Patients Receiving Lysine Analoguesa
| Unadjusted Relative Risk | Covariate Adjusted Relative Risk | |
|---|---|---|
| Blood Product Utilization | ||
| Intra-operative/Early-post Operative (<24 hours) | ||
| Packed Red Blood Cells | 1.20 [1.05, 1.36]* | 0.94 [0.81, 1.09] |
| Fresh Frozen Plasma | 1.07 [0.90, 1.28] | 0.69 [0.55, 0.86]* |
| Cryoprecipitate | 0.70 [0.46, 1.01] | 0.30 [0.18, 0.52]* |
| Platelets | 1.16 [1.04, 1.29]* | 0.95 [0.83, 1.09] |
| Late Post-operative Period (>24 hours) | ||
| Packed Red Blood Cells | 1.35 [1.22, 1.49]* | 0.91 [0.80, 1.04] |
| Fresh Frozen Plasma | 1.99 [1.70, 2.32]* | 1.38 [1.15, 1.66]* |
| Cryoprecipitate | 2.23 [1.38, 3.62]* | 1.66 [0.93, 2.97] |
| Platelets | 1.68 [1.38, 2.05]* | 0.97 [0.76, 1.25] |
| Recombinant Factor VIIa | 0.84 [0.50, 1.42] | 0.22 [0.10, 0.49]* |
| Post-operative Outcome | ||
| MACCE | ||
| Operative Death | 1.72 [0.85, 3.47] | 0.67 [0.25, 1.80] |
| Perioperative MI | --- | |
| Reoperation for Bleeding | 2.90 [1.23, 6.86]* | 2.39 [0.88, 6.48] |
| Neurological Event Permanent | 1.23 [0.44,3.43] | 0.87 [0.25, 3.10] |
| Neurological Event Transient | 2.63 [0.96, 7.18]* | 1.61 [0.50, 5.20] |
| Intra-aortic Balloon Pump | 0.64 [0.24,1.70] | 0.83 [0.25, 2.78] |
| Prolonged Ventilatory/Respiratory Failure | 1.15 [0.81, 1.62] | 0.63 [0.40, 1.00] |
| Renal | ||
| Renal Failure | 1.03 [0.63, 1.69] | 0.59 [0.31, 1.13] |
| Renal Dialysis Required | 2.10 [0.96, 4.58]* | 0.77 [0.27, 2.20] |
| Composite Events | ||
| Renal | 1.03 [0.63, 1.69] | 0.59 [0.31, 1.13] |
| Neurological | 1.85 [0.91, 3.78]* | 1.18 [0.50, 2.78] |
| Length of Stay | ||
| Total Length of Stay | 0.85 [0.73, 0.98]* | 0.98 [0.79, 1.10] |
| Post operative Length of Stay | 0.85 [0.74, 0.98]* | 1.01 [0.83, 1.16] |
a
-Lysine Analogues: tranexamic acid or aminocaproic acid. Values presented as relative risk (RR) and 95% confidence interval as estimated using Poisson or logistic regression for unmatched data or generalized estimating equations (GEE) for matched data. Length of stay outcomes were analyzed using proportional hazards models. MACCE- Major adverse cardiovascular or cerebrovascular event.
*
Indicates a significant finding (p<0.05).