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. Author manuscript; available in PMC: 2012 Sep 22.
Published in final edited form as: Neuron. 2011 Sep 21;71(6):1043–1057. doi: 10.1016/j.neuron.2011.07.009

Figure 6. Interactions among growth-promoting and growth-inhibiting pathways.

Figure 6

(A) dlk-1(lf) is epistatic to mutants displaying enhanced regrowth. In all panels regrowth is normalized to wild type at 24 h; mean ± SEM. (B) Loss of function in pde-4 or gain of function in egl-19 partly suppress unc-57. (C) unc-51, unc-57, and dlk-1 are epistatic to slt-1 in regrowth. (D) DLK-1 overexpression (Prgef-1-DLK-1, juEx2789) can fully suppress the reduced regrowth of unc-51 and unc-57 mutants. (E) Loss of function in efa-6 partly suppresses the reduced regrowth of unc-26, unc-51, and dlk-1, but does not suppress ebp-1 (ebp-1 efa-6 data from Fig. 5 are included for comparison). (F) efa-6 slt-1 double mutants display enhanced regrowth compared to single mutants at 48 h post axotomy. All statistics, t test; n ≥ 10 for each condition except panel D (n ≥ 5); *, P < 0.05; **, P < 0.01; ***, P < 0.001.