Table 2.
Chromosomal features associated with preferential retroviral integration sites.
| Retroviridae genera | in Transcription Unitsa | ± 2kb Transcription Start Sitesa | ± 2 kb CpG Islandsa |
|---|---|---|---|
| Lentiviruses | +/++ | 0 | −/0 |
| Alpharetroviruses | + | 0 | + |
| Betaretroviruses | 0 | 0 | 0 |
| Gammaretroviruses | + | ++ | ++ |
| Deltaretroviruses | + | + | + |
| Epsilonretroviruses | NA | NA | NA |
| Spumaviruses | 0 | ++ | ++ |
| HERV-class II | + | ++ | ++ |
a
ratio between the proportion of the chromosomal feature over the random proportion in the human genome, according to RefSeq databases and with values from [69,87,88,90,94,95].
0: no statistical difference over random;
+/++: statistically favored feature over random with ++ for ratio >2 and + for a ratio <2;
−: statistically disfavored feature over random
NA : not available