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. 2010 Oct 11;2(10):2235–2257. doi: 10.3390/v2102235

Figure 1.

Figure 1

Comparison of the SFFV envelope protein with that of a polytropic MuLV. The unique envelope glycoprotein encoded by SFFV is the sole determinant of its pathogenicity. The envelope precursor of a typical polytropic MuLV is processed to SU and TM proteins. In contrast, the SFFV envelope glycoprotein (Env), due to a large deletion that eliminates the cleavage site between SU and TM, as well as a single base pair insertion in TM, contains fused SU and TM sequences, has a unique transmembrane region and lacks a cytoplasmic tail.