Table 3.
Genetic signatures and/or polymorphisms of HIV-1 non-B subtypes associated with resistance to PIs.
| Drug-associated mutation | Drugs | % in Subtype B | Signatures | Polymorphisms |
|---|---|---|---|---|
| I13V | TPV | 13% | 90%–98% in subtypes A, G and CRF02 | 4%–78% in other subtypes non-B |
| K20I | ATV | 2% | 93%–98% in subtypes G and CRF02 | 1%–3.5% in subtypes A, F and CRF01 |
| M36I | ATV, IDV, NFV and TPV | 13% | 81%–99% in several non-B subtypes | — |
| H69K | TPV | 2% | 96%–97% in subtypes A, C and G, CRF01 and CRF02 | 2% in subtype F |
| V82I | ATV | 2% | 87% in subtype G | 1%–6% in several non-B subtypes |
| I93L | ATV | 33% | 94% in subtype C | 5%–40% in several non-B subtypes |