Table 1.

CD8⁺ T cell epitopes identified in hantavirus proteins ^a.

Epitope	Amino Acid Sequence	Virus	HLA Restriction	Reference
N131–139	LPIILKALY	Sin Nombre	B*3501	[70]
N234–242	ERIDDFLAA	Sin Nombre	Cw7	[70]
G664–673b	TAHGVGIIPM	Sin Nombre	B*3501	[60]
G746–755b	YPWQTAKCFF	Sin Nombre	B*3501	[60]
G465–473c	LMPDVAHSL	Andes	B*3501	[69]
N12–20	NAHEGQLVI	Hantaan	B51	[65]
N421–429	ISNQEPLKL	Hantaan	A1	[65]
N334–342	ILQDMRNTI	Hantaan	A2.1	[71]
L512–520	ILPSKSLEV	Hantaan	A2.1	[71]
L1273–1281	IMELATAGI	Hantaan	A2.1	[71]
L1736–1744	GLDCARLEI	Hantaan	A2.1	[71]
N173–181	RPKHLYVSM	Puumala	B7/B8d	[67]
N204–212	GLFPTQIQV	Puumala	A2.1	[67]
N243–51	ECOFIKPEV	Puumala	B8	[67]
G731–939b	HWMDATFNL	Puumala	A24	[66]

^aFor all epitopes listed, minimal epitopes and HLA restrictions have been determined, and specific T cells have been detected in or specific T cell lines have been generated from human PBMCs;

^bAmino acid numbering is based on the sequence of glycoprotein precursor. These epitopes are located on the Gc;

^cAmino acid numbering is based on the sequence of glycoprotein precursor. This epitope is located on the Gn;

^dRestricted by both HLA-B7 and B8 molecules.