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. 2011 Jul 6;3(7):1059–1073. doi: 10.3390/v3071059

Table 1.

CD8+ T cell epitopes identified in hantavirus proteins a.

Epitope Amino Acid Sequence Virus HLA Restriction Reference
N131–139 LPIILKALY Sin Nombre B*3501 [70]
N234–242 ERIDDFLAA Sin Nombre Cw7 [70]
G664–673b TAHGVGIIPM Sin Nombre B*3501 [60]
G746–755b YPWQTAKCFF Sin Nombre B*3501 [60]
G465–473c LMPDVAHSL Andes B*3501 [69]
N12–20 NAHEGQLVI Hantaan B51 [65]
N421–429 ISNQEPLKL Hantaan A1 [65]
N334–342 ILQDMRNTI Hantaan A2.1 [71]
L512–520 ILPSKSLEV Hantaan A2.1 [71]
L1273–1281 IMELATAGI Hantaan A2.1 [71]
L1736–1744 GLDCARLEI Hantaan A2.1 [71]
N173–181 RPKHLYVSM Puumala B7/B8d [67]
N204–212 GLFPTQIQV Puumala A2.1 [67]
N243–51 ECOFIKPEV Puumala B8 [67]
G731–939b HWMDATFNL Puumala A24 [66]
a

For all epitopes listed, minimal epitopes and HLA restrictions have been determined, and specific T cells have been detected in or specific T cell lines have been generated from human PBMCs;

b

Amino acid numbering is based on the sequence of glycoprotein precursor. These epitopes are located on the Gc;

c

Amino acid numbering is based on the sequence of glycoprotein precursor. This epitope is located on the Gn;

d

Restricted by both HLA-B7 and B8 molecules.