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. 1984 May 25;12(10):4351–4359. doi: 10.1093/nar/12.10.4351

Effects of pH on the stability of chromatin core particles.

L J Libertini, E W Small
PMCID: PMC318836  PMID: 6728680

Abstract

Chromatin core particles near physiological ionic strength undergo a reversible transition induced by changes in pH near neutrality. While sedimentation studies indicate no significant effect on size or shape, changes in tyrosine fluorescence anisotropy and in circular dichroism suggest a somewhat looser structure at high pH. Further support of this suggestion is given by high salt dissociation experiments; at pH 8 core particles begin to show changes at lower salt concentration than at pH 6. The pH transition appears unaffected by the presence of Mg2+ but can be blocked by crosslinking of the histones. A possible relationship is suggested between this transition and increases in intracellular pH which correlate with enhancement in several aspects of cellular activity including DNA replication.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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