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. 1984 Jul 11;12(13):5515–5527. doi: 10.1093/nar/12.13.5515

Coding strategy differences between constant and variable segments of immunoglobulin genes.

P Perrin
PMCID: PMC318936  PMID: 6462913

Abstract

Vertebrate immunoglobulin (Ig) mRNAs reveal intraspecies variation in codon usage distinct from that seen with yeast or bacterial genes. Comparison of all available Ig gene sequences shows that %(G + C) in codon position III is consistently lower in variable (V) segments than in constant (C) segments. I find an even lower %(G + C) in the hypervariable domains of V segments. This analysis suggests that base substitution in Ig genes correlates positively with local A + T content.

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Selected References

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