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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1981 Jan;78(1):9–10. doi: 10.1073/pnas.78.1.9

Biosynthesis of vitamin B12: mode of incorporation of factor III into cobyrinic acid.

C Nussbaumer, M Imfeld, G Wörner, G Müller, D Arigoni
PMCID: PMC318976  PMID: 6938991

Abstract

Extensive chemical degradation of cobyrinic acid biosynthesized from a sample of factor III radiochemically labeled in its three methyl groups demonstrates that label is retained exclusively in the two methyl groups at positions C-2 and C-7 and confirms that the C-20 methyl group of the precursor is lost during formation of the corrin ring system.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bergmann K. H., Deeg R., Gneuss K. D., Kriemler H. P., Müller G. Zur Cobyrinäure-Biosynthese. Gewinnung von Zwischenprodukten der Cobyrinsäure-Biosynthese mit Zellsuspensionen von Propionibacterium shermanii. Hoppe Seylers Z Physiol Chem. 1977 Oct;358(10):1315–1323. [PubMed] [Google Scholar]
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