Abstract
It is shown with the help of radiolabeled substrates that biological formation of the corrin ligand system of cobyrinic acid is linked with the release of an equivalent of acetic acid from a hydroporphinoid precursor in which the C-20 atom has undergone methylation prior to its excision from the macrocycle.
Full text
PDF

Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Battersby A. R., Bushell M. J., Jones C., Lewis N. G., Pfenninger A. Biosynthesis of vitamin B12: identity of fragment extruded during ring contraction to the corrin macrocycle. Proc Natl Acad Sci U S A. 1981 Jan;78(1):13–15. doi: 10.1073/pnas.78.1.13. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Battersby A. R., McDonald E., Hollenstein R., Ihara M., Satoh F., Williams D. C. Biosynthesis of porphyrins and related macrocycles. Part 10. Vitamin B12: biochemical derivation of cobyrinic acid from uroporphyrinogen III. Studies with corresponding ring c methyl heptacarboxylic prophyrinogen, and proof of seven intact methyl transfers. J Chem Soc Perkin 1. 1977;2:166–178. doi: 10.1039/p19770000166. [DOI] [PubMed] [Google Scholar]
- Bergmann K. H., Deeg R., Gneuss K. D., Kriemler H. P., Müller G. Zur Cobyrinäure-Biosynthese. Gewinnung von Zwischenprodukten der Cobyrinsäure-Biosynthese mit Zellsuspensionen von Propionibacterium shermanii. Hoppe Seylers Z Physiol Chem. 1977 Oct;358(10):1315–1323. [PubMed] [Google Scholar]
- Nussbaumer C., Imfeld M., Wörner G., Müller G., Arigoni D. Biosynthesis of vitamin B12: mode of incorporation of factor III into cobyrinic acid. Proc Natl Acad Sci U S A. 1981 Jan;78(1):9–10. doi: 10.1073/pnas.78.1.9. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rasetti V., Pfaltz A., Kratky C., Eschenmoser A. Ring contraction of hydroporphinoid to corrinoid complexes. Proc Natl Acad Sci U S A. 1981 Jan;78(1):16–19. doi: 10.1073/pnas.78.1.16. [DOI] [PMC free article] [PubMed] [Google Scholar]
