Table 2.

Inhibition of tubulin polymerization and colchicine binding by compounds 3g, 3h, 3i, 3j, 4a, and CA4.

Compd	IC50 ± SD [μm][a]	Colch. bind. ± SD [%][b]
3g	1.4 ± 0.01	72 ± 0.5
3h	0.56 ± 0.08	96 ± 0.09
3i	3.1 ± 0.2	56 ± 6
3j	1.6 ± 0.1	49 ± 0.5
4a	> 40	ND
CA-4 (1a)	1.0 ± 0.1	99 ± 3

^[a]Inhibition of tubulin polymerization; the concentration of tubulin was 10 μm.

^[b]Inhibition of [³H]colchicine binding; tubulin, colchicine, and test compound were at 1, 5, and 5 μm, respectively

ND: not determined.