Table 5.
Incidence of systemic complications for the two treatment groups, among patients at risk at baseline.*
| Implant Therapy | Systemic Therapy | Hazard Ratio | P-value | |||
|---|---|---|---|---|---|---|
| #Patients at risk | Cumulative % with event by 2 years (95% CI)‖ | #Patients at risk | Cumulative % with event by 2 years (95% CI)‖ | Impant/Systemic (95% CI)‖ | ||
| Potential complications of corticosteroid therapy‖ | ||||||
| Hyperlipidemia (LDL ≥160 mg/mL) | 97 | 9.8 (5.2, 18.0) | 104 | 11.0 (6.3, 19.1) | 0.91 (039, 2.15) | 0.84 |
| Hyperlipidemia diagnosis requiring treatment | 90 | 1.1(0.2, 7.7) | 86 | 6.0(2.5, 13.8) | 0.19(002, 1.65) | 0.13 |
| Hypertension | ||||||
| Measured SBP≥160 and/or DBP≥100 | 111 | 2.9(0.9, 8.6) | 109 | 10.3(5.8, 17.8) | 0.25 (007, 0.89) | 0.030 |
| Measured SBP≥140 and/or DBP≥90 | 81 | 12.9(7.2, 22.6) | 89 | 26.9(18.4, 37.1) | 0.44 (0.21, 0.92) | 0.030 |
| Hypertension diagnosis requiring treatment | 88 | 4.6(1.8, 11.9) | 88 | 10.5(5.6, 19.3) | 0.40(0.13, 1.29) | 0.13 |
| Diabetes mellitus | 105 | 1.0(0.1, 6.6) | 114 | 3.6(1.4, 9.4) | 0.26 (0.03, 2.44) | 0.24 |
| Bone | ||||||
| Osteopenia | 52 | 25.5(15.7, 39.9) | 63 | 13.0(6.7, 24.4) | 1.98(0.83, 4.70) | 0.12 |
| Osteoporosis | 107 | 4.8(2.0, 11.2) | 108 | 5.0(2.1, 11.6) | 0.95(0, 28, 3.25) | 0.93 |
| Fractures | 125 | 4.1(1.7, 9.5) | 124 | 8.4(4.6, 15.0) | 0.47(0.16, 1.35) | 0.16 |
| Potential complications of immunosuppressive therapy | ||||||
| White blood cell count ≤ 2500 cells/μL | 121 | 0.8(0.1, 5.8) | 120 | 2.6(0.8, 7.7) | 0.33(0.03, 3.15) | 0.34 |
| Platelet count ≤ 100,000/μL | 120 | 2.6(0.8, 7.8) | 118 | 1.7(0.4, 6.6) | 1.43(0.24, 8.35) | 0.69 |
| Hemoglobin ≤10 g/dL | 121 | 0.9(0.1, 6.0) | 118 | 1.8(0.4, 7.0) | 0.88(0.09, 9.00) | 0.92 |
| Elevated liver enzymes¶ | 120 | 5.2(2.4, 11.3) | 120 | 0.9(0.1, 6.0) | 6.45(0.88, 47.2) | 0.066 |
| Elevated creatinine† | 122 | 10.1(5.9, 17.1) | 120 | 5.2(2.4, 11.2) | 2.11(0.80, 5.60) | 0.13 |
| Cancer diagnosis | 126 | 0.8(0.1, 5.5) | 124 | 3.2(1.0, 10.1) | 0.34(0.04, 3.20) | 0.34 |
| Death | 126 | 1.6(0.4, 6.3) | 124 | 0 | Not estimable | |
*
Patients with prevalent complications or missing data at enrollment were excluded from the risk set; the table only assesses first events, not multiple events.
Hazard ratios are adjusted for bilateral disease and uveitis stratum.
‖
LDL = low density lipoprotein; SBP = systolic blood pressure; DBP = diastolic blood pressure; % = percent; CI = confidence interval.
¶
Eleveated liver enzyme is defined as twice the upper limit of normal for aspartate aminotransferase and/or alanine aminotransferase.
†
Elevated creatinine is defined as > 1.5 mg/dL and/or > 30% increase from baseline.