Abstract
Five independently inherited loci on five distinct chromosomes encode the mitochondrial and cytosolic isozymes of NAD-dependent malate dehydrogenase (MDH; L-malate:NAD+ oxidoreductase, EC 1.1.1.37). Multiple alleles, including electrophoretic nulls, occur for each locus. However, a single allele of normal activity at one of the three loci encoding the mitochondrial MDHs is sufficient for normal development, whereas plants with essentially no cytosolic MDH activity function normally. The requirement of a normal activity allele at one of the three structural loci encoding the mitochondrial MDHs demonstrates in plants that a commonly studied dehydrogenase enzyme is essential for normal embryogenesis.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Goodman M. M., Stuber C. W., Lee C. N., Johnson F. M. Genetic control of malate dehydrogenase isozymes in maize. Genetics. 1980 Jan;94(1):153–168. doi: 10.1093/genetics/94.1.153. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McMillin D. E., Scandalios J. G. Duplicated cytosolic malate dehydrogenase genes in Zea mays. Proc Natl Acad Sci U S A. 1980 Aug;77(8):4866–4870. doi: 10.1073/pnas.77.8.4866. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Newton K. J., Schwartz D. Genetic basis of the major malate dehydrogenase isozymes in maize. Genetics. 1980 Jun;95(2):425–442. doi: 10.1093/genetics/95.2.425. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Voelker R. A., Langley C. H., Brown A. J., Ohnishi S., Dickson B., Montgomery E., Smith S. C. Enzyme null alleles in natural populations of Drosophila melanogaster: Frequencies in a North Carolina population. Proc Natl Acad Sci U S A. 1980 Feb;77(2):1091–1095. doi: 10.1073/pnas.77.2.1091. [DOI] [PMC free article] [PubMed] [Google Scholar]