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. 1981 Apr;78(4):2105–2109. doi: 10.1073/pnas.78.4.2105

Translation of phenylalanine hydroxylase-specific mRNA in vitro: evidence for pretranslational control by glucocorticoids.

F Chiappelli, D F Haggerty, M Lynch, G Popják
PMCID: PMC319292  PMID: 6941273

Abstract

We have found that the induction of phenylalanine hydroxylase by hydrocortisone and serum in confluent cultures of H4-II-E-C3 rat hepatoma cells is accompanied by an increase in polysomal mRNA specific for phenylalanine hydroxylase, as measured by translation in a cell-free protein-synthesizing system. Thus, the induction is mediated largely, if not entirely, by a pretranslational mechanism, possibly by stimulation of the transcription of the phenylalanine hydroxylase gene.

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Selected References

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