Table 2.
Relative risk (RR) and 95% confidence intervals (CIs) of renal cell cancer in relation to current use of statin drugs in the Nurses’ Health Study (1994–2008) and the Health Professionals Follow-Up Study (1990–2006)
| Study cohort | Current use of statin drugs
|
|
|---|---|---|
| No | Yes | |
| Women | ||
| Number of cases | 128 | 36 |
| Age-adjusted RR | 1.0 | 0.85 (0.58–1.24) |
| Age & hypertension adjusted RR | 1.0 | 0.75 (0.51–1.10) |
| Multivariate* RR | 1.0 | 0.68 (0.46–1.00) |
| Men | ||
| Number of cases | 83 | 30 |
| Age-adjusted RR | 1.0 | 1.41 (0.91–2.17) |
| Age & hypertension adjusted RR | 1.0 | 1.21 (0.78–1.88) |
| Multivariate* RR | 1.0 | 1.17 (0.75–1.82) |
*
Adjusted for smoking status (never, 1–19, 20–39, ≥40 pack-years), body mass index (<25, 25–26.9, 27–29.9, ≥30 kg/m2), history of hypertension (yes/no), history of diabetes (yes/no), physical activity (quintiles), fruit intake (continuous), vegetable intake (continuous), alcohol intake (continuous), and duration of regular non-aspirin NSAIDs use (no use, >0-<4, 4-<10, ≥10 years), and parity (nulliparous, 1–2, 3, 4, 5+ children) in women.