Table 2.
SNP association with plasma CRP in CLHNS for previously reported variants
| SNP | Nearby Gene | Annotation | Chr | Effect Allele | Non-effect Allele | Previous Studies
|
CLHNS
|
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Effect Allele Freq | Reported β | Reported P | Reference | Effect Allele Freq | β (SE) | P | ||||||
| rs1205 | CRP | 3′ UTR | 1 | C | T | 0.66 | 0.20 | 1.7E-26 | (3) | 0.46 | 0.257 (0.044) | 8.5E-09 |
| rs3091244 | CRP | Promoter | 1 | A/T | C | A:0.07 T:0.31 |
0.20 | 6.2E-28 | (3) | A:0.13 T:0.08 |
0.257 (0.051) | 5.2E-07 |
| rs1169288 | HNF1A | Ile27Leu | 12 | A | C | 0.72 | 0.12 | 2.6E-07 | (4) | 0.66 | 0.265 (0.050) | 1.4E-07 |
| rs2464196 | HNF1A | Ser486Asn | 12 | G | A | 0.69 | 0.14 | 3.3E-13 | (3) | 0.55 | 0.198 (0.044) | 7.5E-06 |
| rs1169286 | HNF1A | Intron | 12 | T | C | 0.61 | 0.10 | 1.6E-06 | (4) | 0.56 | 0.246 (0.049) | 5.1E-07 |
| rs7310409 | HNF1A | Intron | 12 | G | A | 0.57 | 0.15 | 6.8E-17 | (3) | 0.67 | 0.223 (0.046) | 1.6E-06 |
| rs429358 | APOE | Cys130Arg | 19 | T | C | 0.79 | ND | 3.3E-08 | (18) | 0.92 | 0.272 (0.078) | 4.8E-04 |
| rs1892534 | LEPR | Downstream | 1 | C | T | 0.67 | 0.17 | 6.5E-21 | (3) | 0.15 | 0.110 (0.062) | 0.076 |
| rs4129267 | IL6R | Intron | 1 | C | T | 0.67 | 0.10 | 2.0E-08 | (3) | 0.71 | 0.068 (0.058) | 0.24 |
| rs1260326 | GCKR | Leu446Pro | 2 | T | C | 0.43 | 0.16 | 3.6E-14 | (3) | 0.42 | 0.061 (0.048) | 0.20 |
| rs10778213 | 12q23.2 | ---- | 12 | C | T | 0.48 | 0.12 | 1.2E-10 | (3) | 0.80 | 0.027 (0.054) | 0.63 |
Effect allele: the allele that is associated with elevated CRP levels;