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. 1981 May;78(5):3265–3268. doi: 10.1073/pnas.78.5.3265

A highly potent 3200-dalton adrenal opioid peptide that contains both a [Met]- and [Leu]enkephalin sequence.

D L Kilpatrick, T Taniguchi, B N Jones, A S Stern, J E Shively, J Hullihan, S Kimura, S Stein, S Udenfriend
PMCID: PMC319542  PMID: 6265943

Abstract

A 3200-dalton adrenal enkephalin-containing peptide, designated peptide E, that exhibits high opiate activity in the guinea pig ileum longitudinal muscle preparation was purified, and its structure was determined. It contains an amino-terminal [Met]enkephalin sequence and a [Leu]enkephalin sequence at the carboxyl terminus. Sequence analysis revealed that peptide E arises from a previously characterized 4900-dalton adrenal enkephalin-containing peptide. Peptide E was shown to be 30 times more potent than [Met]enkephalin in the guinea pig ileum assay, which suggests that the adrenal enkephalin-containing peptide may perform a unique biological function in vivo.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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