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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Neuropharmacology. 2011 Sep 2;62(1):464–473. doi: 10.1016/j.neuropharm.2011.08.045

Figure 1. Effects of subchronic fluoxetine treatment during stress.

Figure 1

(a) Schematic of experimental timeline. Mice were fluoxetine treated on days 1-16, stressed on days 5-14, and tested in LDE and FST on days 15 and 16, respectively. (b) Non-drug-treated stressed mice spent more time inside the light compartment than non-stressed mice. These differences were absent in fluoxetine-treated mice. (c) Stressed mice made more entries into the light compartment than non-stressed mice after water, but not fluoxetine, treatment. (d) In the FST, stressed mice had higher immobility than non-stressed mice (left). Serum corticosterone levels were higher after the FST in stressed mice than non-stressed mice after non-drug treatment but not fluoxetine treatment (right). Fluoxetine treatment produced higher corticosterone levels than non-drug treatment in non-stressed mice. n=8/treatment/stress condition. Data are means ±SEM. **p<.01, *p<.05 vs. non-drug-treated non-stressed; ‡p<.01 stressed vs. non-stressed; ##p<.01 vs. non-drug/non-stressed