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. Author manuscript; available in PMC: 2012 Nov 11.
Published in final edited form as: Tetrahedron. 2011 Nov 11;67(45):8607–8614. doi: 10.1016/j.tet.2011.09.036

Table 3.

Substituent effect on the hemiacetal formation equilibria of aromatic aldehydes with MeOD

2 σ log Ka
a −0.17 −1.510 −1.510 −1.495
b −0.27 −1.440 −1.996 −1.880
g 0 −1.227 −1.061 −0.974
h 0.23 −0.989 −0.630 −0.568
i 0.78 −0.288 0.477 0.477
a

K=[4]/[2]; K for 1h, 3.5h and 24h