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. 1981 Jun;78(6):3765–3769. doi: 10.1073/pnas.78.6.3765

Organization of four mouse lambda light chain immunoglobulin genes.

B Blomberg, A Traunecker, H Eisen, S Tonegawa
PMCID: PMC319653  PMID: 6791160

Abstract

We have cloned four lambda light chain constant region (C) genes from mouse embryo DNA. Each carries its own joining (J) segment approximately 1.3 kilobases to its 5' side. The four C genes occur in two clusters, 5' J3C3J1C13' and 5' J2C2J4C43', with C4 being a new C lambda gene. We have also shown that V lambda 1 is joined productively with C lambda 3 in a lambda 3-producing myeloma, and it is most likely that V lambda 1 and V lambda 2 are the only V lambda genes. Based on the analysis of the germ line and rearranged variable region (V) lambda genes in myelomas we argue that the V lambda 1 and V lambda 2 genes are at the 5' side of the C3C1 and C2C4 clusters, respectively. We propose that the two clusters arose by duplication. We also speculate on the role of J-associated DNA sequences in regulation of expression of the lambda subtypes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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