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. Author manuscript; available in PMC: 2012 Oct 12.
Published in final edited form as: Structure. 2011 Oct 12;19(10):1509–1517. doi: 10.1016/j.str.2011.07.008

Figure 1. Conserved conformation of Na+/Ca2+ exchanger CALX.

Figure 1

A. Topological model of a Na+/Ca2+ exchanger. NCD represents the not-characterized fragment between TM5 and CBD1. B. Sequence alignment of the intracellular domain of Na+/Ca2+ exchangers from Drosphilia CALX (UniPort entry: CALX_DROME), canine NCX1 (NAC1_CANFA), bovine NCX1 (NAC1_BOVIN), and human NCX1 (NAC1_HUMAN), NCX2 (NAC2_HUMAN) and NAC1 (NAC3_HUMAN). Conserved residues are in rectangles. Identical residues are in black. Secondary structure motifs and the splicing region are for CALX and conserved throughout the family. Seven β-strands from CBD1 or CBD2 are labeled as 1A-1G or 2A-2G.