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. 1981 Jul;78(7):4046–4050. doi: 10.1073/pnas.78.7.4046

On the attribution and additivity of binding energies

William P Jencks 1
PMCID: PMC319722  PMID: 16593049

Abstract

It can be useful to describe the Gibbs free energy changes for the binding to a protein of a molecule, A—B, and of its component parts, A and B, in terms of the “intrinsic binding energies” of A and B, ΔGAi and ΔGBi, and a “connection Gibbs energy,” ΔGs that is derived largely from changes in translational and rotational entropy. This empirical approach avoids the difficult or insoluble problem of interpreting observed ΔH and TΔS values for aqueous solutions. The ΔGi and ΔGs terms can be large for binding to enzymes and other proteins.

Keywords: proteins, ligands, entropy, enzymes

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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