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. 1981 Jul;78(7):4097–4101. doi: 10.1073/pnas.78.7.4097

Characterization of a class of cationic proteins that specifically interact with intermediate filaments.

P M Steinert, J S Cantieri, D C Teller, J D Lonsdale-Eccles, B A Dale
PMCID: PMC319733  PMID: 6170061

Abstract

We describe a class of cationic structural proteins that associate specifically with intermediate filaments (IF) but not with other types of cytoskeletal proteins. These proteins, for which the term filaggrin is introduced, are isolated from the stratum corneum of mammalian epidermis. They are species-distinct proteins; for example, rat and mouse filaggrin have different molecular weights and amino acid compositions, but are nevertheless chemically and functionally ver similar. They interact in vitro with the IF several different types of cells to form large fibers or macrofibrils in which many IF are highly aligned in parallel arrays. Stoichiometric analyses suggest that two molecules of filaggrin bind to each three-chain building block of the IF, possibly by ionic interactions with the coiled-coil alpha-helical regions of the IF.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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