Skip to main content
NCBI home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1981 Jul;78(7):4256–4260. doi: 10.1073/pnas.78.7.4256

Pyochelin: novel structure of an iron-chelating growth promoter for Pseudomonas aeruginosa.

C D Cox, K L Rinehart Jr, M L Moore, J C Cook Jr
PMCID: PMC319768  PMID: 6794030

Abstract

Pyochelin, an endogenous growth promoter that solubilizes ferric iron, has been isolated from Pseudomonas aeruginosa, including clinical strains. The structure of pyochelin has been assigned as 2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid and is of a different type from those previously assigned to siderophores (siderochromes) from bacteria. The assignment rests on 1H and 13C NMR data, high-resolution (including field desorption) mass spectrometry, and spectroscopic properties of synthetic model compounds. Pyochelin is presumed to be biosynthesized from salicylic acid and two moles of cysteine.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bullen J. J., Ward C. G., Wallis S. N. Virulence and the role of iron in Pseudomonas aeruginosa infection. Infect Immun. 1974 Sep;10(3):443–450. doi: 10.1128/iai.10.3.443-450.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cox C. D., Graham R. Isolation of an iron-binding compound from Pseudomonas aeruginosa. J Bacteriol. 1979 Jan;137(1):357–364. doi: 10.1128/jb.137.1.357-364.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cox C. D. Iron uptake with ferripyochelin and ferric citrate by Pseudomonas aeruginosa. J Bacteriol. 1980 May;142(2):581–587. doi: 10.1128/jb.142.2.581-587.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cox C. D. Passage of Pseudomonas aeruginosa in compromised mice. Infect Immun. 1979 Oct;26(1):118–124. doi: 10.1128/iai.26.1.118-124.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Liu P. V., Shokrani F. Biological activities of pyochelins: iron-chelating agents of Pseudomonas aeruginosa. Infect Immun. 1978 Dec;22(3):878–890. doi: 10.1128/iai.22.3.878-890.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Maurer B., Müller A., Keller-Schierlein W., Zähner H. Stoffwechselprodukte von Mikroorganismen. 61. Ferribactin, ein Siderochrom aus Pseudomonas fluorescens Migula. Arch Mikrobiol. 1968;60(4):326–339. [PubMed] [Google Scholar]
  7. O'Brien I. G., Gibson F. The structure of enterochelin and related 2,3-dihydroxy-N-benzoylserine conjugates from Escherichia coli. Biochim Biophys Acta. 1970 Aug 14;215(2):393–402. doi: 10.1016/0304-4165(70)90038-3. [DOI] [PubMed] [Google Scholar]
  8. Pollack J. R., Neilands J. B. Enterobactin, an iron transport compound from Salmonella typhimurium. Biochem Biophys Res Commun. 1970 Mar 12;38(5):989–992. doi: 10.1016/0006-291x(70)90819-3. [DOI] [PubMed] [Google Scholar]
  9. Pruitt B. A., Jr Infections caused by Pseudomonas species in patients with burns and in other surgical patients. J Infect Dis. 1974 Nov;130 (Suppl)(0):S8–13. doi: 10.1093/infdis/130.supplement.s8. [DOI] [PubMed] [Google Scholar]
  10. Snow G. A. Mycobactins: iron-chelating growth factors from mycobacteria. Bacteriol Rev. 1970 Jun;34(2):99–125. doi: 10.1128/br.34.2.99-125.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES