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. 1981 Jul;78(7):4270–4273. doi: 10.1073/pnas.78.7.4270

Metabolic conversion of dibenz[a,h]anthracene (+/-)trans-1,2-dihydrodiol and chrysene (+/-)trans-3,4-dihydrodiol to vicinal dihydrodiol epoxides.

M W Chou, P P Fu, S K Yang
PMCID: PMC319771  PMID: 6945583

Abstract

The hydroxyl groups of dibenz[a,h]anthracene trans-1,2-dihydrodiol and chrysene trans-3,4-dihydrodiol are known to be predominantly in quasi-axial conformations. These dihydrodiols were metabolized by liver microsomes from 3-methylcholanthrene-pretreated rats to form 1,2,3,4-tetrahydrotetrols as the major products. The major metabolites of the dihydrodiols were isolated by reversed-phase high-performance liquid chromatography and identified by ultraviolet--visible absorption and mass spectral analyses. The results indicate that axial hydroxyl groups of dibenz[a,h]anthracene trans-1,2-dihydrodiol and of chrysene trans-3,4-dihydrodiol do not direct metabolism away from their respective vicinal double bond.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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