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. 1981 Feb;78(2):672–675. doi: 10.1073/pnas.78.2.672

Solution conformation of gramicidin S: An intramolecular nuclear Overhauser effect study

Dee-Hua Huang *, Roderich Walter †,‡, Jerry D Glickson §, N Rama Krishna *,§,
PMCID: PMC319861  PMID: 16592969

Abstract

The solution conformation of gramicidin S in deuterated dimethyl sulfoxide was investigated by using the intramolecular nuclear Overhauser effect experiment. Experimental Overhauser enhancements were compared with predicted values for each of the nine most-stable conformations (M1-M9) calculated by Dygert et al. on the basis of energy-minimization procedures [Dygert, M., Gō, N. & Scheraga, H. A. (1975) Macromolecules 8, 750-761]. By using statistical hypothesis testing, the three lowest-energy conformations (M1, M2, and M3) were shown to give the best fit with the experimental data. All other conformations (M4-M9) were found to be inconsistent with the experimental data.

Keywords: proton NMR, antibiotic, peptide, protein

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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