Table 2.
Modification | Amino acid | Responsible enzyme |
Altered activity in HD models |
Antagonisti c enzyme, altered in HD? |
---|---|---|---|---|
SUMOylation | K6, K9, K15 | Rhes | increased | |
ubiquitination | K6, K9, K15 | Ubiquitin E3 ligase eg. E2-25K |
reduced | |
phosphorylati on |
T3 | ? | reduced | |
S13,S16 | IKK | reduced | ||
S421 | Akt1, SGK | unresolve d |
PPT1 / PP2A, reduced |
|
S434 , S1181, S1201 | Cdk5 | reduced | ||
S2076, S2653, S2657 |
ERK1 | reduced | ||
acetylation | K444 | CBP | unknown | HDAC1 |
cleavage | D513 | Caspase-3 | no | |
D552 | Caspase-2/3 | no | ||
D586 | Caspase-6 | increased | ||
T469, S536 | Calpain 1,5,7,10 | increased | ||
104-114, 205-214 | Cathepsin D,B,L | increased | ||
81-129, R167 | Undefined proteases |
unknown | ||
G402 | MMP-10 | increased | ||
palmitoylatio n |
C214 | HIP14 | reduced |