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. 1984 Jul 25;12(14):5583–5588. doi: 10.1093/nar/12.14.5583

An altered DNA sequence encompassing the ras gene of Harvey murine sarcoma virus.

S Yasuda, M Furuichi, E Soeda
PMCID: PMC320016  PMID: 6087292

Abstract

The DNA fragment encompassing the ras gene of Harvey murine sarcoma virus was sequenced and assigned the coding region of a transforming protein, p21, to the sequence. Examination of nucleotide sequence, taken together with the result of analysis of the ras mRNAs (1), has revealed that p21 is encoded from a continuous coding region starting with the 5' proximal initiation codon but not a processed protein. However, there were found several differences between the sequence published by Dhar et. al. (2) and ours, including 9 deletions, 7 substitutions and 2 insertions of nucleotides in the published sequence of 997 nucleotides in length. Among these, one of the substitutions occurring in the coding region resulted in amino acid replacement of glycine by alanine at position 122 of p21. The evidences are presented with some of actual gel autoradiographs.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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