Abstract
A fibre-type x-ray diffraction photograph from thymidylyl-3',5'-thymidine is interpreted in terms of a seven-residues per turn, left-handed helical structure in which the first thymine of one molecule is linked to the second thymine of the next molecule by 'wobble' type hydrogen bonds. The first thymidine is in the anti conformation, with a C2'endo - C3'exo sugar and the second is in the syn conformation with a C3'endo - C4'exo sugar. The C5' - 05' bond in the inter-nucleotide linkage is in the g- conformation and that of the P-05' is g+.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Cornelis A. G., Haasnoot J. H., den Hartog J. F., de Rooij M., van Boom J. H., Cornelis A. Local destabilisation of a DNA double helix by a T--T wobble pair. Nature. 1979 Sep 20;281(5728):235–236. doi: 10.1038/281235a0. [DOI] [PubMed] [Google Scholar]
- Crick F. H. Codon--anticodon pairing: the wobble hypothesis. J Mol Biol. 1966 Aug;19(2):548–555. doi: 10.1016/s0022-2836(66)80022-0. [DOI] [PubMed] [Google Scholar]
- Grosjean H. J., de Henau S., Crothers D. M. On the physical basis for ambiguity in genetic coding interactions. Proc Natl Acad Sci U S A. 1978 Feb;75(2):610–614. doi: 10.1073/pnas.75.2.610. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mellema J. R., van der Woerd R., van der Marel G. A., van Boom J. H., Altona C. Proton NMR study and conformational analysis of d(CGT), d(TCG) and d(CGTCG) in aqueous solution. The effect of a dangling thymidine and of a thymidine mismatch on DNA mini-duplexes. Nucleic Acids Res. 1984 Jun 25;12(12):5061–5078. doi: 10.1093/nar/12.12.5061. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Saenger W., Scheit K. H. A pyrimidine nucleoside in the syn conformation: molecular and crystal structure of 4-thiouridine-hydrate. J Mol Biol. 1970 May 28;50(1):153–169. doi: 10.1016/0022-2836(70)90112-9. [DOI] [PubMed] [Google Scholar]
- Suck D., Saenger W., Main P., Germain G., Declercq J. P. X-ray structure of 3',5'-diacetyl-2'-deoxy-2'-fluorouridine: a pyrimidine nucleoside in the syn conformation. Biochim Biophys Acta. 1974 Sep 13;361(3):257–265. doi: 10.1016/0005-2787(74)90369-4. [DOI] [PubMed] [Google Scholar]
- Wilson H. R., Al-Mukhtar J. Structure of thymidylyl-3',5'-deoxyadenosine. Nature. 1976 Sep 9;263(5573):171–172. doi: 10.1038/263171a0. [DOI] [PubMed] [Google Scholar]
- Wilson H. R. Double helix formed by the dinucleoside phosphate thymidylyl-3',5'-deoxyadenosine. Nature. 1974 Oct 25;251(5477):735–736. doi: 10.1038/251735a0. [DOI] [PubMed] [Google Scholar]