Skip to main content
PMC home page
Nucleic Acids Research logoLink to Nucleic Acids Research
. 1982 May 25;10(10):3279–3289. doi: 10.1093/nar/10.10.3279

The nucleotide sequences of several tRNA genes from rat mitochondria: common features and relatedness to homologous species.

P Cantatore, C De Benedetto, G Gadaleta, R Gallerani, A M Kroon, M Holtrop, C Lanave, G Pepe, C Quagliariello, C Saccone, E Sbisa
PMCID: PMC320706  PMID: 7099963

Abstract

We have determined the nucleotide sequences of thirteen rat mt tRNA genes. The features of the primary and secondary structures of these tRNAs show that those for Gln, Ser, and f-Met resemble, while those for Lys, Cys, and Trp depart strikingly from the universal type. The remainder are slightly abnormal. Among many mammalian mt DNA sequences, those of mt tRNA genes are highly conserved, thus suggesting for those genes an additional, perhaps regulatory, function. A simple evolutionary relationship between the tRNAs of animal mitochondria and those of eukaryotic cytoplasm, of lower eukaryotic mitochondria or of prokaryotes, is not evident owing to the extreme divergence of the tRNA sequences in the two groups. However, a slightly higher homology does exist between a few animal mt tRNAs and those from prokaryotes or from lower eukaryotic mitochondria.

Full text

PDF
3279

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson S., Bankier A. T., Barrell B. G., de Bruijn M. H., Coulson A. R., Drouin J., Eperon I. C., Nierlich D. P., Roe B. A., Sanger F. Sequence and organization of the human mitochondrial genome. Nature. 1981 Apr 9;290(5806):457–465. doi: 10.1038/290457a0. [DOI] [PubMed] [Google Scholar]
  2. Apirion D., Gegenheimer P. Processing of bacterial RNA. FEBS Lett. 1981 Mar 9;125(1):1–9. doi: 10.1016/0014-5793(81)80984-2. [DOI] [PubMed] [Google Scholar]
  3. Arcari P., Brownlee G. G. The nucleotide sequence of a small (3S) seryl-tRNA (anticodon GCU) from beef heart mitochondria. Nucleic Acids Res. 1980 Nov 25;8(22):5207–5212. doi: 10.1093/nar/8.22.5207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bibb M. J., Van Etten R. A., Wright C. T., Walberg M. W., Clayton D. A. Sequence and gene organization of mouse mitochondrial DNA. Cell. 1981 Oct;26(2 Pt 2):167–180. doi: 10.1016/0092-8674(81)90300-7. [DOI] [PubMed] [Google Scholar]
  5. Cedergren R. J., LaRue B., Sankoff D., Lapalme G., Grosjean H. Convergence and minimal mutation criteria for evaluating early events in tRNA evolution. Proc Natl Acad Sci U S A. 1980 May;77(5):2791–2795. doi: 10.1073/pnas.77.5.2791. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Eperon I. C., Anderson S., Nierlich D. P. Distinctive sequence of human mitochondrial ribosomal RNA genes. Nature. 1980 Jul 31;286(5772):460–467. doi: 10.1038/286460a0. [DOI] [PubMed] [Google Scholar]
  7. Kim S. H., Suddath F. L., Quigley G. J., McPherson A., Sussman J. L., Wang A. H., Seeman N. C., Rich A. Three-dimensional tertiary structure of yeast phenylalanine transfer RNA. Science. 1974 Aug 2;185(4149):435–440. doi: 10.1126/science.185.4149.435. [DOI] [PubMed] [Google Scholar]
  8. Kroon A. M., Pepe G., Bakker H., Holtrop M., Bollen J. E., Van Bruggen E. F., Cantatore P., Terpstra P., Saccone C. The restriction fragment map of rat-liver mitochondrial DNA: a reconsideration. Biochim Biophys Acta. 1977 Sep 20;478(2):128–145. doi: 10.1016/0005-2787(77)90177-0. [DOI] [PubMed] [Google Scholar]
  9. Küntzel H., Köchel H. G. Evolution of rRNA and origin of mitochondria. Nature. 1981 Oct 29;293(5835):751–755. doi: 10.1038/293751a0. [DOI] [PubMed] [Google Scholar]
  10. Saccone C., Cantatore P., Gadaleta G., Gallerani R., Lanave C., Pepe G., Kroon A. M. The nucleotide sequence of the large ribosomal RNA gene and the adjacent tRNA genes from rat mitochondria. Nucleic Acids Res. 1981 Aug 25;9(16):4139–4148. doi: 10.1093/nar/9.16.4139. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Schwartz R. M., Dayhoff M. O. Origins of prokaryotes, eukaryotes, mitochondria, and chloroplasts. Science. 1978 Jan 27;199(4327):395–403. doi: 10.1126/science.202030. [DOI] [PubMed] [Google Scholar]
  12. Sprinzl M., Grueter F., Spelzhaus A., Gauss D. H. Compilation of tRNA sequences. Nucleic Acids Res. 1980 Jan 11;8(1):r1–r22. [PMC free article] [PubMed] [Google Scholar]
  13. de Bruijn M. H., Schreier P. H., Eperon I. C., Barrell B. G., Chen E. Y., Armstrong P. W., Wong J. F., Roe B. A. A mammalian mitochondrial serine transfer RNA lacking the "dihydrouridine" loop and stem. Nucleic Acids Res. 1980 Nov 25;8(22):5213–5222. doi: 10.1093/nar/8.22.5213. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Nucleic Acids Research are provided here courtesy of Oxford University Press

RESOURCES