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. 1982 May 25;10(10):3291–3301. doi: 10.1093/nar/10.10.3291

Synthesis of mixed oligodeoxyribonucleotides following the solid phase method.

A Elmblad, S Josephson, G Palm
PMCID: PMC320707  PMID: 7099964

Abstract

A method for the synthesis of mixed dimers, trimers and oligonucleotides on a solid support using monomeric protected nucleoside phosphochloridites (1a-d) has been developed and the different nucleoside reagents, and the results show that yields of different oligomers in a mixture could be directly correlated to the concentration of the four reagents. Separation of mixed oligomers on a reversed phase C18 column has also been studied.

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Selected References

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