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. 1982 Jul 24;10(14):4351–4361. doi: 10.1093/nar/10.14.4351

The influence of the purine 2-amino group on DNA conformation and stability. Synthesis and conformational analysis of d[T(2-aminoA)]3.

B L Gaffney, L A Marky, R A Jones
PMCID: PMC320804  PMID: 7122239

Abstract

A self-complementary hexanucleotide consisting of thymidine and 2-amino-deoxyadenosine, d(TA')3, has been synthesized by a solid phase phosphotriester method. Melting studies show that the additional hydrogen bond afforded by the 2-amino group substantially stabilizes the duplex. Moreover, conformational analysis using circular dichroism shows that a salt-induced conformational transition occurs, similar to the B leads to Z transition observed for d(CG)n oligonucleotides.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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