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. 1982 Jul 24;10(14):4413–4422. doi: 10.1093/nar/10.14.4413

Template directed reactions of 2-aminoadenylic acid derivatives.

T R Webb, L E Orgel
PMCID: PMC320809  PMID: 7122244

Abstract

The template-directed oligomerization of activated derivatives of 2-aminoadenylic acid (paA) on polyuridylic acid (poly(U)) in aqueous buffers was studied. The reaction differs from that of adenylic acid (pA) under identical conditions, in that only di- and tri-nucleotides are observed as substantial products rather than a longer sequence of oligomers. The reaction of paA also differs from that of pA in that it does not require Mg++, and is less susceptible to increased temperature. The relevance of these observations to the chemical evolution of polynucleotide replication is discussed. Improved syntheses of paA and its diphosphate are reported.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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