Table 1.
Characteristics of participants and completion of neurologic rating scales at enrollment into PRION-1 and subsequently
Abbreviations: ADAS-cog = cognitive component of the Alzheimer's Disease Assessment Scale; BPRS = Brief Psychiatric Rating Scale; CDR-SB = Clinical Dementia Rating Scale Sum of Boxes; GCS = Glasgow Coma Scale; GIC = Global Impression of Change; IPD = inherited prion disease; IQR = interquartile range; MMSE = Mini-Mental State Examination; sCJD = sporadic Creutzfeldt-Jakob disease; vCJD = variant Creutzfeldt-Jakob disease.
One patient with MMSE = 15 and moderately ill on GIC did not have Rankin formally recorded at enrollment but is included in the moderate disability Rankin group.
BPRS and Barthel were not done routinely during pilot phase of PRION-1. Barthel measurements were available for some of the 23 pilot patients.
GCS imputed as 15 for all patients with enrollment MMSE ≥10 following the PRION-1 protocol (see appendix e-1).