Abstract
We have developed an integrated computer system for analysis of nucleic acid and protein sequences, which consists of sequence and structure databases, a relational database, and software for structural analysis. The system is potentially applicable to a number of problems in structural biology including predictive classification of the function and location of oncogene products.
Full text
PDF![417](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f464/321015/13712e42ac18/nar00343-0422.png)
![418](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f464/321015/4978d33b19e1/nar00343-0423.png)
![419](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f464/321015/c0e1b289e6ba/nar00343-0424.png)
![420](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f464/321015/1f2248e988d0/nar00343-0425.png)
![421](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f464/321015/4985b024f435/nar00343-0426.png)
![422](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f464/321015/2d16397d4b2d/nar00343-0427.png)
![423](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f464/321015/24a1a0bd701c/nar00343-0428.png)
![424](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f464/321015/34dbf8f29db8/nar00343-0429.png)
![425](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f464/321015/f7ac6c4d013f/nar00343-0430.png)
![426](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f464/321015/6c2844aee9f4/nar00343-0431.png)
![427](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f464/321015/00ed19c732e5/nar00343-0432.png)
![428](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f464/321015/41e711e8b6cb/nar00343-0433.png)
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bernstein F. C., Koetzle T. F., Williams G. J., Meyer E. F., Jr, Brice M. D., Rodgers J. R., Kennard O., Shimanouchi T., Tasumi M. The Protein Data Bank: a computer-based archival file for macromolecular structures. J Mol Biol. 1977 May 25;112(3):535–542. doi: 10.1016/s0022-2836(77)80200-3. [DOI] [PubMed] [Google Scholar]
- Goad W. B., Kanehisa M. I. Pattern recognition in nucleic acid sequences. I. A general method for finding local homologies and symmetries. Nucleic Acids Res. 1982 Jan 11;10(1):247–263. doi: 10.1093/nar/10.1.247. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kanehisa M. I., Goad W. B. Pattern recognition in nucleic acid sequences. II. An efficient method for finding locally stable secondary structures. Nucleic Acids Res. 1982 Jan 11;10(1):265–278. doi: 10.1093/nar/10.1.265. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kanehisa M. I. Los Alamos sequence analysis package for nucleic acids and proteins. Nucleic Acids Res. 1982 Jan 11;10(1):183–196. doi: 10.1093/nar/10.1.183. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smith T. F., Waterman M. S. Identification of common molecular subsequences. J Mol Biol. 1981 Mar 25;147(1):195–197. doi: 10.1016/0022-2836(81)90087-5. [DOI] [PubMed] [Google Scholar]
- Wilbur W. J., Lipman D. J. Rapid similarity searches of nucleic acid and protein data banks. Proc Natl Acad Sci U S A. 1983 Feb;80(3):726–730. doi: 10.1073/pnas.80.3.726. [DOI] [PMC free article] [PubMed] [Google Scholar]