Figure 4. Synergistic effect of cellular microRNAs on regulating cell death during HPAI infection.
4a: Expression patterns of cellular microRNAs and their inversely correlated target genes associated with the cell death in HPAI infected lungs. Red represents microRNA or target gene with increased expression in HPAI- or 2:6-infected samples, relative to Tx-infected samples. Green represents microRNA or target gene with decreased expression in HPAI- or r1918- infected samples, relative to Tx-infected samples. 4b: Network demonstration of the functional connection between inversely correlated target genes associated with cell death during the HPAI infection. Red indicates increased expression in comparison with the Tx infected samples. Both figures represent the results from Day 7 post infection. HPAI: Highly pathogenic virus; 2:6 of intermediate virulence.