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. 1982 Aug 11;10(15):4753–4763. doi: 10.1093/nar/10.15.4753

X-ray crystallographic analysis of 3-(2'-phenyl-2,4'-bithiazole-4-carboxamido) propyldimethylsulphonium iodide, an analogue of the DNA-binding portion of bleomycin A2.

R Kuroda, S Neidle, J M Riordan, T T Sakai
PMCID: PMC321126  PMID: 6182526

Abstract

The crystal and molecular structure of the title compound, an analogue of the DNA binding region of bleomycin A2, has been determined by X-ray crystallography. All the three independent molecules in an asymmetric unit are approximately planar with fully extended side chains. A computer graphics model-building study has shown that the phenyl group and the second thiazole ring can be intercalated between the base pairs of the double-stranded deoxydinucleoside phosphate d(CpG), and also that the sulphonium cation can interact with a backbone phosphate group. This model is in accord with NMR spectral data.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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