Fig. 1.

Fasting glucose is lower and oral glucose tolerance is normal in As^−/− mice. a Data from pooled studies demonstrate that fasting plasma glucose was significantly lower in As^−/− than in wild-type (WT) mice (n≥25 per each genotype). Fasting insulin (b) tended to increase (p=0.07, n≥25) and C-peptide (c) was significantly higher in As^−/− mice (n≥17). d During the GTTs, glucose was reduced in As^−/− (triangles) compared with wild-type (circles) mice, although the changes in glucose and baseline-corrected AUC glucose results were similar. e The baseline-corrected AUC insulin was also similar. *p≤ 0.05, **p≤0.01 between genotypes