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. 2011 Nov 2;5:537–546. doi: 10.2147/PPA.S16854

Willingness to participate in a lifestyle intervention program of patients with type 2 diabetes mellitus: a conjoint analysis

Paul F van Gils 1,, Mattijs S Lambooij 1, Marloes HW Flanderijn 1, Matthijs van den Berg 2, G Ardine de Wit 1,3, Albertine J Schuit 1,4, Jeroen N Struijs 1
PMCID: PMC3218115  PMID: 22114468

Abstract

Background

Several studies suggest that lifestyle interventions can be effective for people with, or at risk for, diabetes. The participation in lifestyle interventions is generally low. Financial incentives may encourage participation in lifestyle intervention programs.

Objective

The main aim of this exploratory analysis is to study empirically potential effects of financial incentives on diabetes patients’ willingness to participate in lifestyle interventions. One financial incentive is negative (“copayment”) and the other incentive is positive (“bonus”). The key part of this research is to contrast both incentives. The second aim is to investigate the factors that influence participation in a lifestyle intervention program.

Methods

Conjoint analysis techniques were used to empirically identify factors that influence willingness to participate in a lifestyle intervention. For this purpose diabetic patients received a questionnaire with descriptions of various forms of hypothetical lifestyle interventions. They were asked if they would be willing to participate in these hypothetical programs.

Results

In total, 174 observations were rated by 46 respondents. Analysis showed that money was an important factor independently associated with respondents’ willingness to participate. Receiving a bonus seemed to be associated with a higher willingness to participate, but having to pay was negatively associated with participation in the lifestyle intervention.

Conclusion

Conjoint analysis results suggest that financial considerations may influence willingness to participate in lifestyle intervention programs. Financial disincentives in the form of copayments might discourage participation. Although the positive impact of bonuses is smaller than the negative impact of copayments, bonuses could still be used to encourage willingness to participate.

Keywords: incentives, bonus, copayment, conjoint analysis, willingness to participate

Background

Lifestyle intervention programs can be defined as a planned and targeted approach to change the behavior of people with the aim of promoting health or preventing disease. Lifestyle intervention programs can have a positive impact on public health, for example, by reducing risk factors for diabetes complications like high blood pressure, high cholesterol level, and high body weight.13 These interventions could potentially also slow down the increasing prevalence of type 2 diabetes mellitus,46 expected to be 366 million worldwide by the year 2030.7

A major challenge in lifestyle intervention programs is to increase willingness to join, as participation in such programs is in general relatively low. For instance, a weight-loss program for obese patients in the United States only had a 40% participation rate, ie, adherence and compliance.8,9 Also, only 15% of eligible persons participated in a German disease management program.10 In the latter study, the main reason for participation was that their health insurer offered clients to join.

The lower the participation rate in a lifestyle program, the smaller the public health impact might be.8,11 It is therefore important to get a better understanding of peoples’ willingness to participate in lifestyle intervention programs. There are different techniques to measure why people participate in interventions. One of them is the conjoint analysis technique.1215 This quantifies the relative importance of characteristics of a lifestyle intervention in program participation decisions. Obviously, this information can also be used to explore why people are not willing to participate in lifestyle intervention programs. Previous conjoint analysis study results suggest that people are willing to pay to participate in lifestyle interventions but they do not seem willing to pay full program costs.16 Moreover, individuals with high perceived risks seem willing to pay more compared with individuals with low perceived risks. An alternative technique for conjoint analysis is to use a standard questionnaire and simply ask why people decided to (or not) participate in a lifestyle intervention program. Studies that investigated reasons for not participating using this technique, suggest that affordability is a barrier to participate.17,18 For instance, potential participants indicate that they cannot afford to pay the relatively higher prices for better quality food or they cannot afford to pay for use of sport facilities. The conjoint analysis and standard questionnaire findings suggest that money is associated with participation in lifestyle intervention programs. Germany seems the first country to use positive financial incentives (bonuses) to encourage active participation in primary and secondary prevention.19

To the best of the authors’ knowledge no empirical research has been performed to analyze the effect of various types of financial incentives on participation in lifestyle intervention programs. The main aim of this paper is to explore empirically potential differences of two types of financial incentives on diabetes patients’ willingness to participate in lifestyle interventions. One financial incentive is negative (“copayment”) and the other is positive (“bonus”). The key part of this research is to contrast both incentives. The secondary aim is to examine which other factors of a lifestyle intervention program are associated with diabetes patients’ willingness to participate.

Methods

Conjoint analysis

The conjoint analysis technique was used to examine which factors are associated with willingness to participate in a hypothetical lifestyle intervention program. In a conjoint analysis a hypothetical lifestyle intervention program is described in terms of characteristics (attributes). The technique presents hypothetical scenarios (vignettes) to respondents that vary with respect to the levels of the attributes. 20 Respondents are asked if they would be willing to participate in the hypothetical lifestyle intervention program. Conjoint analysis has an important advantage compared with standard questionnaire research: people are forced to make trade-offs and they cannot indicate that all factors of a lifestyle intervention program are of equal importance.

Literature to determine conjoint scenarios

A literature search was carried out to determine the vignette attributes. Search terms were: lifestyle program, lifestyle modification, physical activity, exercise, adherence, compliance, and participation. For this search the databases PubMed, Cochrane, PsycINFO, and Picarta were used.

Factors that seem to influence willingness to participate in lifestyle intervention programs include time, costs, counseling, the kind of sports activity in the program, and the composition of the group.17,18,2124 Based on the literature findings six attributes were created. They are presented in Table 1. Next, levels were assigned to the attributes. Majority of the attribute levels were dummies and the money attributes were chosen in a range wide enough to likely influence respondents hypothetical choices. Obviously, how much they influence the hypothetical choices is the empirical question trying to be answered.

Table 1.

Attributes and levels

Attribute Levels
Time spent on the program 2.5 hours per week
4 hours per week
Arrangement physical activity lessons Individually with men and women
With people of the same gender
Group activity Only with people without diabetes
Only with other diabetes patients
Sports activity Walking/cycling
Fitness (treadmill, rowing machine, bicycle)
Counseling None
Physical therapist/sports teacher
Money Copayment = €500 per year
Copayment = €327.50 per year
Copayment = €155 per year
Copayment = €0 per year
Bonus = €0 per year
Bonus = €155 per year
Bonus = €327.5 per year
Bonus = €500 per year
*

Notes: Half of the research population received a conjoint questionnaire in which they had to pay for participating in the hypothetical lifestyle intervention. The other half received a questionnaire in which they received money for participation.

The main aim of this study was to test for potential differences between a negative (copayment) and a positive (bonus) financial incentive to participate in hypothetical lifestyle intervention programs. Therefore, the research population was randomly divided into two groups. One group received a conjoint questionnaire in which they had to pay a hypothetical copayment to participate in the hypothetical lifestyle intervention and the other group received a conjoint questionnaire in which they received a hypothetical bonus to participate in the hypothetical lifestyle intervention. Please note that all other attributes were exactly similar between both versions of the conjoint questionnaire. Appendix A presents the details of the design of the conjoint experiment that was used in this study.

Study population

Patient questionnaires were distributed in 2009 among type 2 diabetes patients by two specialized nurses in general practices. None of the diabetes patients had previously participated in a lifestyle intervention program, nor had complications or comorbidities. One nurse distributed 63 questionnaires to patients visiting the clinic and another nurse sent out 192 questionnaires to a random selection of her patients. All respondents were asked to complete the conjoint analysis on a voluntary basis. The study did not require approval of a medical ethics committee as the questionnaire did not include questions which can intervene in the psychological state of the participants.

Statistical analysis

Respondents’ characteristics were analyzed using frequencies. A logistic regression was used to analyze conjoint scenarios as the focus was on the willingness of respondents to participate in the hypothetical lifestyle program: answering categories yes vs no. Results of the linear probability model were also presented for ease of interpretation. The influence of respondents’ characteristics on the willingness to participate in a lifestyle intervention program was also analyzed. The statistical program used for the analyses was Stata (v 11; StataCorp LP, College Station, TX).

As the key part of the analysis was to test for potential differences between the hypothetical copayment and bonus, a spline was included in the logistic regression analyses. A spline is a combination of variables in a regression analysis. It consists of a main effect, a dummy variable indicating a possible bend in the regression slope (the knot), and an interaction variable. The spline enables a test of whether the slope of the copayment differs from the slope of the bonus.25 In other words, it was tested if the coefficients of copayment and bonus have the same impact on willingness to participate using an F-test. Moreover, the dummy variable enables a test for whether respondents’ values for not receiving a bonus and not having to pay copayment differ between scenarios in which they received a bonus compared with scenarios in which they had to pay a copayment. The main reason for including a spline in the regression models is that people might react differently to a scenario with a negative financial incentive compared with a scenario with a positive financial incentive. Appendix B gives a detailed explanation of the construction of the spline and a detailed explanation of its interpretation.

Results

Study population

In total, 174 observations were rated by 46 respondents (18% of the distributed questionnaires) implying that not all respondents answered four conjoint scenarios.

The majority of respondents were Dutch (97.7%), and men and women were equally represented (50.0%). Their mean age was 67.3 years (standard deviation 11.2) and about 25% was above 75 years of age. Mean body mass index (BMI) was 28.8 kg/m² (standard deviation 5.7). Twenty percent of the respondents had a low income and most of them were retired (53.7%). As the characteristics age, sex, nationality, and BMI of this study population correspond to those characteristics found in a large observational study on diabetic patients in the Netherlands,26,27 this sample can be considered representative of the Dutch diabetic population.

Regression analyses

Table 2 presents the results of the regression models without correction for confounders. The signs of the logistic regression coefficients (B) represent the relations between the attribute levels and respondents’ willingness (or not) to participate. The P values are only statistically significant for the attribute “money” (P = 0.01) and the interaction “money*receiving” P = 0.050). As only these money attributes are statistically significant, it seems that only money influences willingness to participate. The positive sign of the “money” attribute suggests a positive association between money (either a bonus or a decreasing copayment) and willingness to participate. The negative sign of the interaction “receiving*money” indicates that the effect on participation is smaller in the case where the patient receives a bonus. The negative coefficient of “ receiving” reflects the difference of the zero option (the value of 0 of the attribute money) between respondents which had answered conjoint scenarios with only bonuses vs conjoint scenarios containing only copayments.

Table 2.

Results of regression models based on the attributes of participation in the hypothetical lifestyle interventions (N = 46; N observations = 174)

Attributes Logistic regression model Linear probability model


B Odds ratio 95% CI P value B 95% CI P value
Time spent on the program
(reference category = 2.5 hours)
4 hours −0.067 0.935 0.448 to 1.953 0.863 −0.018 −0.162 to 0.126 0.803
Arrangement of physical activity lessons
(reference category = with men and women)
With people of the same gender 0.577 1.780 0.729 to 4.347 0.243 0.098 −0.072 to 0.269 0.249
Individually 0.405 1.500 0.622 to 3.619 0.402 0.066 −0.102 to 0.235 0.432
Group activity
(reference category = only with people without diabetes)
Only with other diabetes patients 0.490 1.633 0.786 to 3.392 0.168 0.088 −0.041 to 0.218 0.176
Sports activity
(reference category = walking/cycling)
Fitness (treadmill, rowing machine, bicycle) 0.467 1.595 0.771 to 3.296 0.206 0.076 −0.058 to 0.209 0.258
Counseling
(reference category = no counseling)
Counseling from a physical therapist/sports instructor 0.281 1.325 0.631 to 2.783 0.513 0.046 −0.110 to 0.203 0.551
Money 0.006 1.006 1.002 to 1.011 0.025 0.0008 0.000 to 0.001 0.014
Copayment = €500 per year
Copayment = €327.50 per year
Copayment = €155 per year
€0 per year
Bonus = €155 per year
Bonus = €327.50 per year
Bonus = €500 per year
Receiving −0.429 0.651 0.220 to 1.930 0.579 −0.051 −0.370 to 0.266 0.744
Interaction receiving*money −0.006 0.994 0.990 to 0.999 0.050 −0.0006 −0.002 to 0.000 0.126
Intercept −1.258 0.284 0.098 to 0.827 0.045 0.226 −0.017 to 0.468 0.067

Abbreviations: CI, confidence interval; €, euro.

The corresponding coefficient of the linear probability model suggest that money increases the willingness to participate in a lifestyle intervention program with 0.08% per euro increase in bonus or decrease in copayment (B = 0.0008). However, the statistically significant interaction variable of the spline (B = −0.057; P = 0.050) suggests that the slope for paying money differs from the slope of receiving money. For paying money the slope is positive (main effect of money B = 0.0008; P = 0.014), but for receiving money the slope flattens out (for receiving money the B of the interaction variable “money*receiving” is added to the main effect [0.0008 + −0.0006 = 0.0002]). The (nontabulated) F-test was significant for both linear and logistic analyses (linear F = 4.93, P = 0.032; logistic F = 4.73, P = 0.029). Although the coefficients of the slope of receiving seem very small, in absolute terms with a bonus €500 per year the associated increase in willingness to participate is substantial (10%).

The results of the analyses that include background variables age, BMI, and sex are presented in Table 3a. These additional analyses showed that the probability of participating is positively influenced by “limiting a lifestyle program to only diabetes patients” and “by supervision and counseling of an instructor” by 13.4% and 15.8%, respectively (linear probability model). Moreover, older people are less willing to participate in a lifestyle intervention program. Additional analyses showed that the increasing number of statistical significant attributes compared to Table 2 was caused by the exclusion of respondents with missing background variables and not by the case-mix adjustments (results not shown). Since it is likely that income may influence the results we also present the analysis including income. However, information on income was only available for 32 respondents (Table 3b). Even in this analysis with fewer respondents the effect of money on willingness to participate remains.

Table 3a.

Results of regression models based on the attributes of participation in the hypothetical lifestyle interventions: adjusted for gender, age, and BMI (N = 37; N observations = 158)

Attributes Logistic regression model Linear probability model


B Odds ratio 95% CI P value B 95% CI P value
Time spent on the program
(reference category = 2.5 hours)
4 hours −0.441 0.643 0.324 to 1.279 0.208 −0.092 −0.214 to 0.030 0.134
Arrangement of physical activity lessons
(reference category = with men and women)
With people of the same gender 0.408 1.503 0.570 to 3.975 0.409 0.069 −0.093 to 0.232 0.389
Individually −0.009 0.991 0.317 to 3.099 0.987 0.011 −0.177 to 0.199 0.908
Group activity
(reference category = only with people without diabetes)
Only with other diabetes patients 0.735 2.085 0.975 to 4.459 0.058 0.134 0.008 to 0.261 0.038
Sports activity
(reference category = walking/cycling)
Fitness (treadmill, rowing machine, bicycle) 0.577 1.780 0.751 to 4.225 0.191 0.095 −0.053 to 0.244 0.202
Counseling
(reference category = no counseling)
Counseling from a physical therapist/sports instructor 1.01 2.746 1.094 to 6.876 0.031 0.158 0.009 to 0.307 0.038
Money 0.008 1.008 1.002 to 1.015 0.010 0.001 0.000 to 0.002 0.001
Copayment = €500 per year
Copayment = €327.50 per year
Copayment = €155 per year
€0 per year
Bonus = €155 per year
Bonus = €327.50 per year
Bonus = €500 per year
Receiving −1.417 0.230 0.068 to 0.857 0.028 −0.243 −0.486 to −0.001 0.049
Interaction receiving*money −0.007 0.993 0.986 to 0.999 0.030 −0.001 −0.002 to 0.000 0.061
Gender
(reference category = women)
−0.262 0.770 0.331 to 1.790 0.543 −0.064 −0.208 to 0.079 0.368
Age
(reference category < 75 years of age)
−1.417 0.242 0.064 to 0.918 0.037 −0.236 −0425 to −0.047 0.016
BMI
(reference category < BMI 30 kg/m2)
−0.360 0.698 0.241 to 2.014 0.506 −0.048 −0237 to 0.141 0.611
Intercept −0.272 0.762 0.202 to 2.863 0.687 0.418 0.168 to 0.669 0.002

Abbreviations: BMI, body mass index; CI, confidence interval; €, euro.

Table 3b.

Results of regression models based on the attributes of participation in the hypothetical lifestyle interventions: adjusted for gender, age, BMI, and income (N = 32; N observations = 125)

Attributes Logistic regression model Linear probability model


B Odds ratio 95% CI P value B 95% CI P value
Time spent on the program
(reference category = 2.5 hours)
4 hours −0.335 0.715 0.295 to 1.735 0.458 −0.084 −0.245 to 0.0770 0.295
Arrangement of physical activity lessons
(reference category = with men and women)
With people of the same gender 0635 1.887 0.526 to 6.773 0.330 0.097 −0.111 to 0.305 0.349
Individually 0.444 1.559 0.430 to 5.652 0.500 0.072 −0.148 to 0.294 0.506
Group activity
(reference category = only with people without diabetes)
Only with other diabetes patients 0.531 1.701 0.698 to 4.145 0.243 0.101 −0.054 to 0.257 0.193
Sports activity
(reference category = walking/cycling)
Fitness (treadmill, rowing machine, bicycle) 0.731 2.077 0.742 to 5.818 0.164 0.116 −0.077 to 0.310 0.230
Counseling
(reference category = no counseling)
Counseling from a physical therapist/sports instructor 0.908 2.482 0.870 to 7.078 0.089 0.152 −0.024 to 0.329 0.089
Money 0.009 1.009 1.001 to 1.016 0.021 0.001 0.000 to 0.002 0.002
Copayment = €500 per year
Copayment = €327.50 per year
Copayment = €155 per year
€0 per year
Bonus = €155 per year
Bonus = €327.50 per year
Bonus = €500 per year
Receiving −1.711 0.181 0.044 to 0.738 0.017 −0.304 −0.577 to −0.031 0.030
Interaction receiving * money −0.006 0.994 0.987 to 1.002 0.132 −0.001 −0.001 to 0.000 0.252
Sex
(reference category = women)
−0.921 0.912 0.386 to 2.155 0.834 −0.026 −0.185 to 0.134 0.744
Age
(reference category < 75 years of age
−1.058 0.347 0.082 to 1.461 0.149 −0.215 −0.477 to 0.046 0.103
BMI
(reference category < BMI 30 kg/m2)
−0.614 1.848 0.172 to 1.704 0.294 −0.099 −0.300 to 0.101 0.319
Income
(reference category = low income)
0.427 1.533 0.405 to 5.789 0.529 0.071 −0.152 to 0.294 0.522
Intercept −0.463 0.629 0.130 to 3.056 0.566 0.410 0.097 to 0.723 0.012

Abbreviations: BMI, body mass index; CI, confidence interval; €, euro.

It is worth noting, however, that in Tables 3a and 3b the dummy variable “receiving” seems statistically significant. This seems to indicate that the zero option (‘not having to pay a copayment’ in case of copayments or ‘not receiving a bonus’ in case of bonuses) is valued lower by respondents that received a questionnaire including bonuses compared with respondents that received a questionnaire with copayments.

Discussion

Lifestyle intervention programs can have a positive impact on public health but program participation is often quite low. This study investigated the factors, particular financial factors, underlying type 2 diabetes patients’ willingness to participate in a lifestyle program. A conjoint analysis was applied to measure respondents’ preferences regarding a lifestyle program. This study explored empirically potential differences between positive (bonus) and negative ( copayment) financial incentives on diabetes patients’ willingness to participate in lifestyle intervention programs.

The main finding of this study suggests that copayment is inversely related to the willingness to participate in a lifestyle intervention program. In other words, copayment can discourage participation in the program. This finding is consistent with an earlier finding using conjoint analysis, which showed unwillingness to pay by high-risk individuals for diabetes risk-reduction programs.16 Receiving a bonus seems to be associated with a higher willingness to participate in the program although the coefficients for each euro received is smaller compared with the negative coefficients of copayments. This result seems also consistent with findings in the literature. Rewards for following a lifestyle program are less effective in contrast to rewards for attendance of vaccination or screening programs,28 and there is insufficient evidence of the effectiveness of rewards to promote lifestyle changes.2931 The analysis corrected for potential confounders like age, BMI, sex, and income showing that the main conclusion does not change.

A strength of this study is that the conjoint analysis included both a copayment and a bonus. This enabled a test for possible differences between positive and negative incentives. The main advantage of a conjoint analysis is that it can be used to gain insights in the relative importance of intervention attributes and the way people value these attributes.

A limitation of this study is the small group of respondents. Although the 174 observations are sufficient to report the results on the vignette-level, a proper analysis among subgroups of patients requires a much larger sample.3234 Factors underlying willingness to participate in a lifestyle intervention should be studied more extensively. Therefore further research should preferably use larger samples facilitating analysis of relevant subgroups. Another limitation of this study is the limited knowledge on the external validity of the answers of the conjoint analysis. To what extent do the answers reflect hypothetical scenario choices made in everyday life? Although progress in comparing, stated in a questionnaire, with revealed preferences (people’s actual behavior) has been performed in other healthcare settings,35 evidence in the field of health promotion is scarce. Therefore empirical research to test for potential differences between the impact of copayments and bonuses on willingness to participate in lifestyle intervention programs using revealed preferences compared with stated preferences is encouraged.

It would be interesting if future research could explore the differences in respondents’ values for not having to pay to participate (related to scenarios with a bonus) compared to having to pay a copayment (related to scenarios with copayments). It is worth taking these differences into account in study designs as this sample was split, but one could consider testing if this result remains the same if the same people value zeros compared with a bonus and with a copayment.

Conclusion

This study showed that financial considerations may influence willingness to participate in lifestyle intervention programs. Copayments could therefore discourage participation. Although the positive impact of bonuses is smaller than the negative impact of copayments, bonuses could still be used to encourage willingness to participate.

Appendix A.

Design conjoint analysis: attributes and levels

The combination of six attributes and levels (two attributes with four levels, one attribute with three levels, and one attribute with four levels) gave rise to 24 × 31 × 41 = 192 hypothetical lifestyle intervention programs (possible scenarios). Each participant randomly received a set of four out of 48 sets of scenarios (the 192 scenarios were clustered in 48 sets of four scenarios).

One of the challenges in designing a conjoint analysis experiment is to avoid the combination of unrealistic attributes and levels in one scenario.36 In order to make sure that presented scenarios were realistic, several items were rephrased. Another design challenge is to avoid respondents being confronted with scenario-attributes that are similar (similarity in the set of four scenarios they received), resulting in reduced motivation for the respondents due to a boring task. Therefore, it was tested if more than three questionnaires had four or more scenario-attributes that were similar. If this was the case, a new randomization was started. A second measure was that the questionnaires were constructed by multiple vignette-universes (ie, a set of all possible vignette combinations): five datasets with the 192 vignettes were constructed and they were each separately randomly ordered. This meant that each unique vignette could be rated five times, but that it was always combined with other vignettes. This decreased the risk that any vignette was combined more than once with other vignettes that were similar. So even when a vignette was judged by a respondent who became less motivated because of too little variation between the vignettes, a similar vignette would be judged by another respondent who was still motivated because the choices in their questionnaire varied sufficiently.

Conjoint analysis: survey questions

Respondents were first asked to rate the four hypothetical lifestyle interventions with a grade ranging from “1” to “10,” where “1” was defined as really dislike the lifestyle intervention and “10” as really like the lifestyle intervention. The rating exercise measures which aspects of the lifestyle intervention participants valued.14,37 Subsequently, respondents were asked whether or not they would be willing to participate in the hypothetical lifestyle interventions (answering categories “yes” or “no”).

A communication expert was consulted to adjust the wording of the conjoint analysis questionnaire in an attempt to avoid bias due to incorrect interpretation of the conjoint questions. Figure A1 presents an example of a hypothetical life style intervention (a scenario).

Figure A1.

Figure A1

Example scenario.

Note: *Results were not used in this paper.

Appendix B.

Spline in regression models

A spline enables a test of whether the slope of a negative financial incentive (“copayment”) differs from the slope of a positive financial incentive (“bonus”) for participation in the hypothetical lifestyle intervention (scenario).25 The main reason for including a spline is that people might react differently to a scenario when they are asked to pay compared with receiving money for a similar scenario. A spline was constructed using three variables. The first variable expressed the amount of money received or paid (ranging from −€500 to €500; see Table 1). By means of this variable, the association between the amount of money and the probability of participation in the lifestyle intervention is tested. The second variable is a dummy with the value 0 in case of a set of scenarios stating that the respondents would have to pay vs the value 1 for scenarios indicating that people would receive money in return for participation in the lifestyle intervention program. This dummy is called the “knot” and it defines the place where the slope of the model may change. Third, an interaction of these two variables was entered into the logistic regression analyses. When the slope before the knot (here: negative values of money, or the negative side of the x-axis) differs from the slope after the knot (here: positive values of money, or the positive side of the x-axis), this interaction will yield a statistically significant result. Together these three variables enable a test of whether the slopes and the continuance of the logistic regression analyses differ between negative and positive financial incentives for participation in hypothetical lifestyle intervention programs.

Footnotes

Disclosure

The authors report no conflicts of interest in this work.

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