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. 1985 Jul 25;13(14):5189–5202. doi: 10.1093/nar/13.14.5189

Nuclease-hypersensitive sites in chromatin of the estrogen-inducible apoVLDL II gene of chicken.

K Kok, L Snippe, G Ab, M Gruber
PMCID: PMC321858  PMID: 4022779

Abstract

DNAseI-hypersensitive sites were localized in apoVLDL II chromatin from chicken. In the liver two sites at 1.75 and 1.0 kb upstream from the cap-site are present before the gene is activated. After induction by estradiol a number of additional sites appear, three in the promotor region of the gene, one within the coding region and two behind the poly-A signal. These sites disappear when the expression of the gene is shut off upon estradiol withdrawal. All sites appear to be tissue-specific in that they are not found in other tissues of the rooster. However, in oviduct of the laying hen we find a hypersensitive site at 1.6 kb in front of the gene.

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Selected References

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