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. 2010 Nov 3;152(1):19–25. doi: 10.1210/en.2010-1012

Figure 1.

Figure 1

The SRC-3Δ4 isoform acts a signaling adaptor for EGF-dependent cancer cell migration and invasion. A, Comparative structures of full-length SRC-3 and the SRC-3Δ4 isoform. The basic-helix-loop-helix, Per/ARNT/Sim, receptor interaction, and activation domains are denoted by bHLH, PAS, RID, and AD, respectively; Q denotes the glutamine-rich region (7). The three phosphorylation sites in the SRC-3Δ4 isoform that are essential for its signal adaptor function in growth factor signaling are indicated. B, Phosphorylated SRC-3Δ4 acts as a signaling adaptor for EGF→FAK→c-Src transduction pathway that leads to cancer cell migration, invasion, and metastasis (see text for details).