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. Author manuscript; available in PMC: 2012 Nov 22.
Published in final edited form as: Biochemistry. 2011 Oct 31;50(46):10013–10026. doi: 10.1021/bi201292e

Figure 1.

Figure 1

Panel a shows the Fgp41 amino acid sequence with regions encompassing the fusion peptide, N-helix, and C-helix in blue, red, and green, respectively. Panel b is a conceptual representation of gp41 structural states with time increasing from left to right and the same color coding as panel a. The sequence is from the HIV-1 clade A isolate, AY288087 or Q45D5. This is a primary isolate from a female patient in Kenya. The last eight residues of the sequence are non-native. The red and green regions were based on continuous helical regions in high-resolution structures of different soluble ectodomain gp41 constructs with Hairpin conformation (shown schematically in panel b). In these SHB structures, the red and green helices are antiparallel to one another.