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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Pain. 2011 Oct 14;152(12):2802–2812. doi: 10.1016/j.pain.2011.09.005

Fig. 3.

Fig. 3

TGFβ1 transcription activity is altered among TMD−WPT and TMD+WPT cases. Fold-change in transcription factor activities for TMD−WPT and TMD+WPT cases across cell type and experimental condition are shown. TGFβ1 activity was consistently inhibited in cases relative to controls in 24 activity profiles. Fold-inductions or fold-inhibitions among the remaining 47 transcription reporter constructs did not differ between cases and controls. Data are the number of fold-inductions (values above 0) or fold-inhibitions (values below 0) out of 32 activity profiles per transcription factor in TMD−WPT and TMD+WPT cases relative to healthy controls. The solid line set at 0 represents no change relative to controls, while the dashed lines set at 22 and −22 represent cut-offs corresponding to the number of inductions or inhibitions expected by chance based on a two-tailed binomial probability test. The value for TGFβ1 fell outside the boundaries of the chance expectation, and therefore is statistically significant (P<0.05).