Skip to main content
NCBI home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1969 Jan;48(1):146–155. doi: 10.1172/JCI105963

Some determinants of the effects of VAL-5-angiotensin II amide on glomerular filtration rate and sodium excretion in dogs

John C McGiff 1, James R Lynch 1, Jeffrey A Leinicke 1, James C Strand 1, Ali Aboosi 1
PMCID: PMC322200  PMID: 4303789

Abstract

In 12 dogs anesthetized with chloralose, angiotensin (angiotensin II amide) given intravenously increased the glomerular filtration rate (GFR) of an ischemic kidney while simultaneously having little effect on the GFR of the contralateral kidney. In the ischemic kidney, in 14 of 30 observations, increments of GFR greater than 100% of mean control GFR (9 ml/min) occurred in response to angiotensin. The magnitude of the increase in GFR produced by angiotensin was independent of dose (range 0.005-0.050 μg/kg per min), the degree of accompanying pressor response, and alterations in renal blood flow (RBF) (electromagnetic flow-meter). In the ischemic kidney, increments of GFR could be produced by sub-pressor doses of angiotensin.

Dissociations between increments of GFR and sodium excretion occurred. Equivalent increments of GFR in the ischemic kidney in dogs receiving either 5% glucose in water or 10% mannitol in 0.3% saline were associated with natriuresis only in the latter group: a) as an initial response of the contralateral kidney to renal arterial constriction (RAC) in spite of a concomitant reduction in RBF and an unchanged GFR; b) in the ischemic kidney on giving angiotensin. The natriuresis produced by angiotensin was independent of the magnitude of elevations in blood pressure, altered filtration fraction, and was associated with a further reduction in RBF. After release of RAC in the dogs receiving mannitol, an antinatriuresis was again observed in response to angiotensin.

The presence of unilateral renal ischemia allowed the demonstration of a differential action of angiotensin on the GFR of an ischemic and nonischemic kidney. The natriuresis in response to angiotensin requires, in addition to mannitol, the participation of undefined factors invoked by unilateral renal ischemia.

Full text

PDF
146

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARAJAS L. THE INNERVATION OF THE JUXTAGLOMERULAR APPARATUS. AN ELECTRON MICROSCOPIC STUDY OF THE INNERVATION OF THE GLOMERULAR ARTERIOLES. Lab Invest. 1964 Aug;13:916–929. [PubMed] [Google Scholar]
  2. BORKOWSKI A. J., HOWARDS S. S., LARAGH J. H. ANTIOTENSIN AND ELECTROLYTE EXCRETION IN RENOVASCULAR HYPERTENSION. Am J Physiol. 1965 Jun;208:1087–1092. doi: 10.1152/ajplegacy.1965.208.6.1087. [DOI] [PubMed] [Google Scholar]
  3. Blythe W. B., Welt L. G. Plasma sodium concentrations and urinary sodium excretion. Trans Assoc Am Physicians. 1965;78:90–96. [PubMed] [Google Scholar]
  4. Bonjour J. P., Regoli D., Roch-Ramel F., Peters G. Prerequisites for the natriuretic effect of val-5-angiotensin II amide in the rat. Am J Physiol. 1968 May;214(5):1133–1138. doi: 10.1152/ajplegacy.1968.214.5.1133. [DOI] [PubMed] [Google Scholar]
  5. Cannon P. J., Ames R. P., Laragh J. H. Indirect action of angiotensin infusion to inhibit renal tubular sodium reabsorption in dogs. Am J Physiol. 1966 Oct;211(4):1021–1030. doi: 10.1152/ajplegacy.1966.211.4.1021. [DOI] [PubMed] [Google Scholar]
  6. Dirks J. H., Cirksena W. J., Berliner R. W. Micropuncture study of the effect of various diuretics on sodium reabsorption by the proximal tubules of the dog. J Clin Invest. 1966 Dec;45(12):1875–1885. doi: 10.1172/JCI105492. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Earley L. E., Friedler R. M. The effects of combined renal vasodilatation and pressor agents on renal hemodynamics and the tubular reabsorption of sodium. J Clin Invest. 1966 Apr;45(4):542–551. doi: 10.1172/JCI105368. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. FUHR J., KACZMARCZYK J., KRUTTGEN C. D. Eine einfache colorimetrische Methode zur Inulinbestimmung für Nieren-Clearance-Untersuchungen bei Stoffwechselgesunden und Diabetikern. Klin Wochenschr. 1955 Aug 1;33(29-30):729–730. doi: 10.1007/BF01473295. [DOI] [PubMed] [Google Scholar]
  9. GOMEZ D. M. Evaluation of renal resistances, with special reference to changes in essential hypertension. J Clin Invest. 1951 Oct;30(10):1143–1155. doi: 10.1172/JCI102534. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. HEALY J. K., BARCENA C., O'CONNELL J. M., SCHREINER G. E. RENAL AND PRESSOR ACTION OF ANGIOTENSIN IN THE NORMAL DOG. Am J Physiol. 1965 Jun;208:1093–1099. doi: 10.1152/ajplegacy.1965.208.6.1093. [DOI] [PubMed] [Google Scholar]
  11. KAMM D. E., LEVINSKY N. G. INHIBITION OF RENAL TUBULAR SODIUM REABSORPTION BY HYPERNATREMIA. J Clin Invest. 1965 Jul;44:1144–1150. doi: 10.1172/JCI105221. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Koch K. M., Dume T., Krause H. H., Ochwadt B. Intratubulärer Druck, glomerulärer Capillardruck und Glomerulumfiltrat während Mannit-Diurese. Pflugers Arch Gesamte Physiol Menschen Tiere. 1967;295(1):72–79. [PubMed] [Google Scholar]
  13. Lamport H. THE EFFECTS ON RENAL RESISTANCE TO BLOOD FLOW OF RENIN, ANGIOTONIN, PITRESSIN AND ATROPINE, HYPERTENSION, AND TOXEMIA OF PREGNANCY. J Clin Invest. 1942 Nov;21(6):685–695. doi: 10.1172/JCI101345. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Laragh J. H., Cannon P. J., Bentzel C. J., Sicinski A. M., Meltzer J. I. ANGIOTENSIN II, NOREPINEPHRINE, AND RENAL TRANSPORT OF ELECTROLYTES AND WATER IN NORMAL MAN AND IN CIRRHOSIS WITH ASCITES. J Clin Invest. 1963 Jul;42(7):1179–1192. doi: 10.1172/JCI104803. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Laragh J. H. Renin, angiotensin, aldosterone and hormonal regulation of arterial pressure and salt balance. Introductory remarks. Fed Proc. 1967 Jan-Feb;26(1):39–41. [PubMed] [Google Scholar]
  16. Leyssac P. P. Intrarenal function of angiotensin. Fed Proc. 1967 Jan-Feb;26(1):55–59. [PubMed] [Google Scholar]
  17. Lindheimer M. D., Lalone R. C., Levinsky N. G. Evidence that an acute increase in glomerular filtration has little effect on sodium excretion in the dog unless extracellular volume is expanded. J Clin Invest. 1967 Feb;46(2):256–265. doi: 10.1172/JCI105528. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. MCGIFF J. C., ITSKOVITZ H. D. LOSS OF THE RENAL VASOCONSTRICTOR ACTIVITY OF ANGIOTENSIN II DURING RENAL ISCHEMIA. J Clin Invest. 1964 Dec;43:2359–2367. doi: 10.1172/JCI105110. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Malvin R. L., Vander A. J. Effects of angiotensin infusion on renal function in the unanesthetized rat. Am J Physiol. 1967 Nov;213(5):1205–1208. doi: 10.1152/ajplegacy.1967.213.5.1205. [DOI] [PubMed] [Google Scholar]
  20. Martino J. A., Earley L. E. The effects of infusion of water on renal hemodynamics and the tubular reabsorption of sodium. J Clin Invest. 1967 Jul;46(7):1229–1238. doi: 10.1172/JCI105616. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. McGiff J. C., Burns R. B., Blumenthal M. R. Role of acetylcholine in the renal vasoconstrictor response to sympathetic nerve stimulation in the dog. Circ Res. 1967 Jun;20(6):616–629. doi: 10.1161/01.res.20.6.616. [DOI] [PubMed] [Google Scholar]
  22. McGiff J. C., Fasy T. M. The relationship of the renal vascular activity of angiotensin II to the autonomic nervous system. J Clin Invest. 1965 Nov;44(11):1911–1923. doi: 10.1172/JCI105297. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. McGiff J. C. Natriuretic effect of angiotensin in dogs revealed after administration of reserpine and guanethidine. Circ Res. 1967 Jun;20(6):664–675. doi: 10.1161/01.res.20.6.664. [DOI] [PubMed] [Google Scholar]
  24. Ng K. K., Vane J. R. Conversion of angiotensin I to angiotensin II. Nature. 1967 Nov 25;216(5117):762–766. doi: 10.1038/216762a0. [DOI] [PubMed] [Google Scholar]
  25. Peters G. Effects of val-5-angiotensin II-amide and of hydrochlorothiazide on the kidneys of renal hypertensive rats. Nephron. 1965;2(2):95–106. doi: 10.1159/000179379. [DOI] [PubMed] [Google Scholar]
  26. Porush J. G., Kaloyanides G. J., Cacciaguida R. J., Rosen S. M. The Effects of Angiotensin II on Renal Water and Electrolyte Excretion in Normal and Caval Dogs. J Clin Invest. 1967 Dec;46(12):2109–2122. doi: 10.1172/JCI105698. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. SCHMID H. E. Renin, a physiologic regulator of renal hemodynamics? Circ Res. 1962 Jul;11:185–193. doi: 10.1161/01.res.11.1.185. [DOI] [PubMed] [Google Scholar]
  28. Szabó G., Magyar S. Effect of hypertonic mannitol solution on circulation and renal function in acute blood loss. Acta Med Acad Sci Hung. 1967;23(4):325–335. [PubMed] [Google Scholar]
  29. THURAU K. RENAL HEMODYNAMICS. Am J Med. 1964 May;36:698–719. doi: 10.1016/0002-9343(64)90181-0. [DOI] [PubMed] [Google Scholar]
  30. Thurau K. Influence of sodium concentration at macula densa cells on tubular sodium load. Ann N Y Acad Sci. 1966 Nov 22;139(2):388–399. doi: 10.1111/j.1749-6632.1966.tb41212.x. [DOI] [PubMed] [Google Scholar]
  31. VANDER A. J. Inhibition of distal tubular sodium reabsorption by angiotensin. II. Am J Physiol. 1963 Jul;205:133–138. doi: 10.1152/ajplegacy.1963.205.1.133. [DOI] [PubMed] [Google Scholar]
  32. VANDER A. J., MILLER R. CONTROL OF RENIN SECRETION IN THE ANESTHETIZED DOG. Am J Physiol. 1964 Sep;207:537–546. doi: 10.1152/ajplegacy.1964.207.3.537. [DOI] [PubMed] [Google Scholar]
  33. Vander A. J. Control of renin release. Physiol Rev. 1967 Jul;47(3):359–382. doi: 10.1152/physrev.1967.47.3.359. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES