Abstract
Studies have been made of movement of various macromolecules into and out of the pleural space of guinea pigs during the course of a delayed hypersensitivity reaction to purified protein derivative (PPD), and a passively transferred immediate hypersensitivity reaction to ovalbumin. While the immediate hypersensitivity reaction transiently alters vascular permeability as shown by increased movement of macromolecules into the chest, the delayed hypersensitivity reaction is marked by a decreased capacity to resorb macromolecules from the pleural space. The data suggest that the two hypersensitivity reactions may be distinguished by these physiologic differences. Additional data from studies of a chemically induced pleural effusion in these animals suggest that some type of outflow obstruction is necessary for the development of effusion, but that the outflow defect caused by the irritating chemical is based on a different mechanism than that seen during the delayed hypersensitivity reaction.
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- ARNASON B. G., WAKSMAN B. H. TUBERCULIN SENSITIVITY. IMMUNOLOGIC CONSIDERATIONS. Bibl Tuberc. 1964;19:1–97. [PubMed] [Google Scholar]
- Allen J. C., Apicella M. A. Experimental pleural effusion as a manifestation of delayed hypersensitivity to tuberculin PPD. J Immunol. 1968 Sep;101(3):481–487. [PubMed] [Google Scholar]
- BRANN I., NILSSON O. [Morphology of the visceral pleura of the guinea pig in experimentally induced exudation. 2. Light and electron microscopically demonstrable changes in allergic pleurisy]. Beitr Pathol Anat. 1963 Apr;128:122–138. [PubMed] [Google Scholar]
- BRANN I., NILSSON O. [The morphology of guinea pig visceral pleura in experimentally induced exudation. 1. Changes in irritative pleurisy which can be determined by light microscopy and electron microscopy]. Beitr Pathol Anat. 1962 Dec;127:406–423. [PubMed] [Google Scholar]
- CHIEN S., SINCLAIR D. G., CHANG C., PERIC B., DELLENBACK R. J. SIMULTANEOUS STUDY OF CAPILLARY PERMEABILITY TO SEVERAL MACROMOLECULES. Am J Physiol. 1964 Sep;207:513–517. doi: 10.1152/ajplegacy.1964.207.3.513. [DOI] [PubMed] [Google Scholar]
- COCHRANE C. G., WEIGLE W. O., DIXON F. J. The role of polymorphonuclear leukocytes in the initiation and cessation of the Arthus vasculitis. J Exp Med. 1959 Sep 1;110:481–494. doi: 10.1084/jem.110.3.481. [DOI] [PMC free article] [PubMed] [Google Scholar]
- COURTICE F. C., SIMMONDS W. J. Absorption of fluids from the pleural cavities of rabbits and cats. J Physiol. 1949 Aug;109(1-2):117–130. doi: 10.1113/jphysiol.1949.sp004375. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HUNTER W. M., GREENWOOD F. C. Preparation of iodine-131 labelled human growth hormone of high specific activity. Nature. 1962 May 5;194:495–496. doi: 10.1038/194495a0. [DOI] [PubMed] [Google Scholar]
- Ham K. N., Hurley J. V. Acute inflammation: an electron-microscope study of turpentine-induced pleurisy in the rat. J Pathol Bacteriol. 1965 Oct;90(2):365–377. doi: 10.1002/path.1700900202. [DOI] [PubMed] [Google Scholar]
- OVARY Z. Immediate reactions in the skin of experimental animals provoked by antibody-antigen interaction. Prog Allergy. 1958;5:459–508. [PubMed] [Google Scholar]
- Ovary Z., Spitz E., De Szalay C. PCA and RPCA in guinea pigs with rabbit and guinea pig antibodies and different antigens. J Immunol. 1966 Oct;97(4):559–563. [PubMed] [Google Scholar]
- RAYBUCK H. E., WEATHER FORD T., ALLEN L. Lymphatics in genesis of ascites in the rat. Am J Physiol. 1960 Jun;198:1207–1210. doi: 10.1152/ajplegacy.1960.198.6.1207. [DOI] [PubMed] [Google Scholar]
- STEARMAN R. L. Statistical concepts in microbiology. Bacteriol Rev. 1955 Sep;19(3):160–215. doi: 10.1128/br.19.3.160-215.1955. [DOI] [PMC free article] [PubMed] [Google Scholar]
- STEWART P. B., BURGEN A. S. The turnover of fluid in the dog's pleural cavity. J Lab Clin Med. 1958 Aug;52(2):212–230. [PubMed] [Google Scholar]