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. 1969 May;48(5):930–939. doi: 10.1172/JCI106052

Plasma Progesterone and 17-hydroxyprogesterone in normal men and children with congenital adrenal hyperplasia

Charles A Strott 1, Teruya Yoshimi 1, Mortimer B Lipsett 1
PMCID: PMC322302  PMID: 4305376

Abstract

Plasma 17-hydroxyprogesterone (17-OHP) concentrations in normal men averaged 0.094 μg/100 ml. Studies using suppressive doses of androgens and glucocorticoids showed that 90% of the 17-OHP originated from the Leydig cell. The 17-OHP production rate was 1.8 mg/24 hr. Plasma 17-OHP has a marked circadian variation, the 8 p.m. values being only 40% of the 8 a.m. values. Plasma luteinizing hormone measured in the same samples did not vary.

The adrenal cortex has the capacity to synthesize and secrete 17-OHP and progesterone since adrenocorticotrophic hormone (ACTH) caused a fourfold increase in these plasma steroids. In children with congenital adrenal hyperplasia, plasma 17-OHP levels were 50-200 times those of normal men and plasma progesterone was increased 6- to 10-fold over normal men.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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