Abstract
Expression of the rate of inactivation of isonicotinoyl hydrazide (INH) as a first-order constant gave better discrimination of slow and rapid inactivators than did the level of INH at the end of 6 hr. The most probable division point between the two classes was at k = 0.130.
Rate of inactivation by obligatory heterozygotes was determined. Such heterozygotes could not be adequately differentiated from homozygous rapid inactivators.
The gene frequency for slow inactivation was 0.46 ±0.04 in Alaskan Eskimos and 0.62±0.06 in Athabaskan Indians.
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Selected References
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