Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1969 Oct;48(10):1888–1894. doi: 10.1172/JCI106155

Effect of expansion of extracellular fluid volume on renal phosphate handling

Wadi N Suki 1,2, Manuel Martinez-Maldonado 1,2, Diane Rouse 1,2, Arthur Terry 1,2
PMCID: PMC322425  PMID: 5822594

Abstract

To examine the specific effect of extracellular fluid (ECF) volume expansion on phosphate excretion studies were performed in thyroparathyroidectomized dogs receiving saline solution intravenously. The natriuresis resulting from ECF volume expansion was consistently accompanied by an increase in phosphate excretion. The possible role of increased filtered load of phosphate was eliminated in experiments in which the filtered load of phosphate was reduced by acute reduction in the glomerular filtration rate. Despite considerable reductions in filtered phosphate, ECF volume expansion resulted in a consistent increase in phosphate excretion. Furthermore, the possible contribution of alteration in blood composition was investigated in experiments in which saline was infused during thoracic inferior vena cava constriction. In these experiments saline infusion failed to increase sodium or phosphate excretion. Cessation of saline infusion and release of caval constriction resulted in a prompt natriuresis and increased phosphate excretion. It is concluded from these studies that extracellular fluid volume expansion results in an increased phosphate excretion in the parathyroidectomized dog. This effect is the specific consequence of ECF volume expansion and is not due to increase in the filtered load of phosphate or alterations in blood composition.

Full text

PDF
1888

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLYTHE W. B., WELT L. G. DISSOCIATION BETWEEN FILTERED LOAD OF SODIUM AND ITS RATE OF EXCRETION IN THE URINE. J Clin Invest. 1963 Sep;42:1491–1496. doi: 10.1172/JCI104833. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Blythe W. B., Gitelman H. J., Welt L. G. Effect of expansion of the extracellular space on the rate of urinary excretion of calcium. Am J Physiol. 1968 Jan;214(1):52–57. doi: 10.1152/ajplegacy.1968.214.1.52. [DOI] [PubMed] [Google Scholar]
  3. Cirksena W. J., Dirks J. H., Berliner R. W. Effect of thoracic cava obstruction on response of proximal tubule sodium reabsorption to saline infusion. J Clin Invest. 1966 Feb;45(2):179–186. doi: 10.1172/JCI105330. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. DIRKS J. H., CIRKSENA W. J., BERLINER R. W. THE EFFECTS OF SALINE INFUSION ON SODIUM REABSORPTION BY THE PROXIMAL TUBULE OF THE DOG. J Clin Invest. 1965 Jul;44:1160–1170. doi: 10.1172/JCI105223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Earley L. E., Friedler R. M. The effects of combined renal vasodilatation and pressor agents on renal hemodynamics and the tubular reabsorption of sodium. J Clin Invest. 1966 Apr;45(4):542–551. doi: 10.1172/JCI105368. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Elwood C. M., Sigman E. M. The measurement of glomerular filtration rate and effective renal plasma flow in man by iothalamate 125-I and iodopyracet 131-I. Circulation. 1967 Sep;36(3):441–448. doi: 10.1161/01.cir.36.3.441. [DOI] [PubMed] [Google Scholar]
  7. Fulop M., Brazeau P. The phosphaturic effect of sodium bicarbonate and acetazolamide in dogs. J Clin Invest. 1968 May;47(5):983–991. doi: 10.1172/JCI105813. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Johnston C. I., Davis J. O. Evidence from cross circulation studies for a humoral mechanism in the natriuresis of saline loading. Proc Soc Exp Biol Med. 1966 Apr;121(4):1058–1063. doi: 10.3181/00379727-121-30965. [DOI] [PubMed] [Google Scholar]
  9. Lichardus B., Pearce J. W. Evidence for a humoral natriuretic factor released by blood volume expansion. Nature. 1966 Jan 22;209(5021):407–409. doi: 10.1038/209407a0. [DOI] [PubMed] [Google Scholar]
  10. Massry S. G., Coburn J. W., Chapman L. W., Kleeman C. R. Effect of NaCl infusion on urinary Ca++ and Mg++ during reduction in their filtered loads. Am J Physiol. 1967 Nov;213(5):1218–1224. doi: 10.1152/ajplegacy.1967.213.5.1218. [DOI] [PubMed] [Google Scholar]
  11. Rasmussen H., Pechet M., Fast D. Effect of dibutyryl cyclic adenosine 3',5'-monophosphate, theophylline, and other nucleotides upon calcium and phosphate metabolism. J Clin Invest. 1968 Aug;47(8):1843–1850. doi: 10.1172/JCI105874. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Rector F. C., Jr, Martinez-Maldonado M., Kurtzman N. A., Sellman J. C., Oerther F., Seldin D. W. Demonstration of a hormonal inhibitor of proximal tubular reabsorption during expansion of extracellular volume with isotonic saline. J Clin Invest. 1968 Apr;47(4):761–773. doi: 10.1172/JCI105771. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. SELDIN D. W., TARAIL R. Effect of hypertonic solutions on metabolism and excretion of electrolytes. Am J Physiol. 1949 Oct;159(1):160–174. doi: 10.1152/ajplegacy.1949.159.1.160. [DOI] [PubMed] [Google Scholar]
  14. STRICKLER J. C., THOMPSON D. D., KLOSE R. M., GIEBISCH G. MICROPUNCTURE STUDY OF INORGANIC PHOSPHATE EXCRETION IN THE RAT. J Clin Invest. 1964 Aug;43:1596–1607. doi: 10.1172/JCI105035. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Suki W. N., Schwettmann R. S., Rector F. C., Jr, Seldin D. W. Effect of chronic mineralocorticoid administration on calcium excretion in the rat. Am J Physiol. 1968 Jul;215(1):71–74. doi: 10.1152/ajplegacy.1968.215.1.71. [DOI] [PubMed] [Google Scholar]
  16. WALSER M. Calcium clearance as a function of sodium clearance in the dog. Am J Physiol. 1961 May;200:1099–1104. doi: 10.1152/ajplegacy.1961.200.5.1099. [DOI] [PubMed] [Google Scholar]
  17. WESSON L. G., Jr Magnesium, calcium, and phosphate excretion during osmotic diuresis in the dog. J Lab Clin Med. 1962 Sep;60:422–432. [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES