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. 1970 Feb;49(2):274–281. doi: 10.1172/JCI106237

Increased Vascular permeability produced by human platelet granule cationic extract

Ralph L Nachman 1, Babette Weksler 1, Barbara Ferris 1
PMCID: PMC322470  PMID: 4391559

Abstract

A cationic protein extract obtained from isolated human platelet granules increased vascular permeability in mouse and rabbit skin. The permeability-enhancing effect was not inhibited by soybean trypsin and pancreatic trypsin inhibitor, methylsergide maleate, carboxypeptidase B, and C[unk]1 inactivator. Permeability-enhancing activity was blocked by prior treatment of challenged animals with antihistamine. The nondializable relatively heat-stable cationic granule protein extract possessed potent mastocytolytic activity. The experiments described suggest that human platelets exert a permeability-enhancing effect by lysosomal release of cationic proteins which cause histamine release from adjacent tissue mast cells.

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Selected References

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