Table.

Non-local and local changes requested by local research ethics committees after approval by multicentre research ethics committees

Non-local changes or comments requested	No of times requested (% of committees)	Local changes or comments requested	No of times requested (% of committees)
Changes to information sheets	22 (18)	Local staff to be notified	11 (9)
Changes to consent procedure	12 (10)	Ethnic mix to be considered	10 (8)
Changes to questionnaire	9 (7)	Local investigator to be identified	6 (5)
Changes to methods of recruiting subjects	9 (7)	Information sheets to be on locally headed paper	4 (3)
Changes to protocol	5 (4)	Approval required from local research and development office	3 (2)
Confidentiality issues	4 (3)	Confirmation of locally incurred costs	3 (2)
		Exclusions for subjects already in research	2 (2)
		Maximum number to be recruited from local site	1 (1)
		Researchers' credentials to be supplied	1 (1)
		Local research ethics committee number to be written on local documents	1 (1)